Agilent, 653950-702, AdvanceBio Oligonucleotide, 4.6 x 150 mm, 2.7 µm

AdvanceBio Oligonucleotide, 4.6 x 150 mm, 2.7 µm. Reversed-phase HPLC column designed for high-resolution IP-RP separation of oligos. Scalable chemistry platform supports analytical through prep purification for optimal resolution, yield, and purity.

Specifications:
Brand: AdvanceBio Oligonucleotide
Hardware: SS
Inner Diameter (ID): 4.6 mm
LC Platform: Stainless Steel
Length: 150 mm
Maximum Temperature: 65 °C
Part Number Application: Oligos
Part Number Application Domain: BiopharmaPharmaceutical
Particle Size: 2.7 µm
Particle Type: Superficially Porous
Phase: HPH-C18
Pore Size: 120 Å
Pressure Rating: 600 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LC & LC/MS
UNSPSC Code: 41115711
pH Range: 3-11

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Engineered for high-performance separation and analysis of synthetic oligonucleotides, this 4.6 x 150 mm column with 2.7 micron particle size delivers exceptional resolution and sensitivity in liquid chromatography workflows. It utilizes superficially porous particle technology to provide robust, reproducible results while minimizing backpressure, enabling efficient method development and routine quality control in oligonucleotide research.

Ideal for laboratories focused on therapeutic oligo development, gene editing, or nucleic acid purity assessment, the column is optimized for the separation of single- and double-stranded oligonucleotides with varying lengths and modifications. Its design allows precise detection of sequence variants, truncation products, and impurities, supporting both research and biopharmaceutical environments.

Compatible with leading UHPLC and HPLC systems, including Agilent’s InfinityLab and 1260/1290 series, as well as other major instrument platforms, the column integrates seamlessly into existing workflows. For even greater analytical performance, it can be paired with Agilent’s AdvanceBio LC instrumentation and buffers tailored for nucleic acid analysis. Researchers benefit from improved throughput and consistent, reliable data, making this column an essential tool for oligonucleotide characterization and quality control in modern genomics and life science laboratories.