Agilent, 795775-904, AdvanceBio RP-mAb C4, 2.1 x 100 mm, 3.5 µm

AdvanceBio RP-mAb C4, 2.1 x 100 mm, 3.5 µm. A reversed-phase C4 HPLC column with superficially porous particles and a wide (450 Å) pore size designed for mAbs and other larger proteins for intact or subunit analysis.

Specifications:
Brand: AdvanceBio RP mAb C4
Hardware: SS
Inner Diameter (ID): 2.1 mm
LC Platform: Stainless Steel
Length: 100 mm
Maximum Temperature: 90 °C
Part Number Application Domain: Biopharma
Part Number Application: Intact & Subunit AnalysisMonoclonal Antibodies (mABs)Proteins
Particle Size: 3.5 µm
Particle Type: Superficially Porous
Phase: C4
Pore Size: 450 Å
Pressure Rating: 600 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LCLC & LC/MS
UNSPSC Code: 41115711
pH Range: 1-8

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Engineered for high-resolution monoclonal antibody (mAb) analysis, this reverse phase C4 column features a 2.1 x 100 mm dimension and a 3.5 micron particle size, making it ideal for advanced biopharmaceutical separations. It utilizes a robust silica support and proprietary surface chemistry to deliver reliable performance for rapid, high-throughput peptide mapping, intact and subunit mAb analysis, and quality control workflows. Suitable for both denaturing and reducing conditions, this column maintains protein integrity and peak shape even with demanding samples.

Optimized for use with UHPLC and HPLC systems, including Agilent 1290 Infinity and 1260 Infinity series, it ensures reproducible retention times and minimized carryover. Researchers can achieve consistent results in characterization, comparability studies, and method development for therapeutic antibody pipelines. The 3.5 micron particle size supports balanced speed and resolution, accommodating a range of sample complexities.

Compatible with a wide array of mobile phase conditions, this column integrates seamlessly into existing workflows alongside related AdvanceBio columns for C18 and Protein A based separations. With robust lot-to-lot reproducibility and dependable performance, it is a critical component for analytical laboratories focused on precision protein analysis in biologics development and QA testing.