Agilent, PL1945-1802, PL-SCX 1000Å, 2.1 x 50 mm, 8 µm

PL-SCX 1000Å, 2.1 x 50 mm, 8 µm. A strong cation exchange HPLC column with fully porous PS/DVB particles. This column can withstand a wide pH range (1-14) and is stable at elevated temperatures.

Specifications:
Brand: PL-SCX
Hardware: SS
Inner Diameter (ID): 2.1 mm
LC Platform: Stainless Steel
Length: 50 mm
Maximum Temperature: 80 °C
Part Number Application: Proteins
Part Number Application Domain: Biopharma
Particle Size: 8 µm
Particle Type: Fully Porous
Phase: SCX
Pore Size: 1000 Å
Pressure Rating: 207 bar
Separation Mode: Ion Exchange (IEX)
Shipping Solvent: 0.1M Sodium Sulfate
Technique: LC
UNSPSC Code: 41115711
pH Range: 1-14

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This strong cation exchange (SCX) HPLC column features a 1000 Angstrom pore size, a compact 2.1 x 50 mm format, and robust 8 micron particle design, enabling effective separation of a broad range of biomolecules based on charge differences. It is particularly suited for high-performance purification and characterization of proteins, peptides, and other charged analytes in biopharmaceutical, proteomics, and life science research. The large pore structure supports the analysis of higher molecular weight species, making it ideal for monoclonal antibodies and other large protein samples in method development and quality assurance processes.

Engineered for compatibility with most standard HPLC and UHPLC systems, this SCX column integrates smoothly into established workflows for ion exchange chromatography. It is recommended for researchers requiring high selectivity and reproducibility in complex sample matrices. Typical applications include charge variant analysis, isoform profiling, and the resolution of post-translationally modified proteins. The column can be used in conjunction with a range of Agilent and third-party chromatography systems, and is part of an extended portfolio of ion exchange and reversed-phase columns, supporting comprehensive separation strategies in advanced analytical laboratories.