BD, 349527, BD Simultest™ Anti-Human CD8 FITC/CD38 PE

Reactivity: Human
Application: Flow cytometry
Regulatory Status: RUO (GMP)
RRID: AB_2075539
Storage Buffer: Phosphate buffered saline with gelatin and 0.1% sodium azide.
Description: Description The CD8 antibody, clone SK1, is derived from hybridization of NS-1 mouse myeloma cells with spleen cells from BALB/c mice immunized with human peripheral blood T lymphocytes. The CD38 antibody, clone HB-7, is derived from hybridization of P3-X63-Ag8.653 mouse myeloma cells with spleen cells from BALB/c mice immunized with the BJAB cell line. The CD8 (Leu-2a) antigen is present on the human suppressor/cytotoxic T-lymphocyte subset as well as on a subset of natural killer (NK) lymphocytes. The CD8 antigenic determinant interacts with class I major histocompatibility complex (MHC) molecules resulting in increased adhesion between the CD8 + T lymphocytes and the target cells. Binding of the CD8 antigen to class I MHC molecules enhances the activation of resting T lymphocytes. CD8 recognizes an antigen expressed on the 32-kdalton (kDa) α-subunit of a disulfide-linked bimolecular complex. The cytoplasmic domain of the α-subunit of the CD8 antigen is associated with the protein tyrosine kinase p56 lck . CD38 (Leu-17) recognizes an antigen that is an integral membrane glycoprotein, Mr 45 kDa, with a protein core of 35 kDa.
Preparation And Storage: Preparation And Storage Store vials at 2°C–8°C. Conjugated forms should not be frozen. Protect from exposure to light. Each reagent is stable until the expiration date shown on the bottle label when stored as directed.
Description : Clone : Isotype : EntrezGene ID
N/A : N/A : | IgG1, κ,IgG1, κ : N/A