Waters, 186008953, BioResolve RP mAb Polyphenyl Column, 450Å, 2.7 µm, 4.6 mm X 50 mm, 1/pk

The first choice for reverse phase protein separation and analysis, BioResolve RP mAb Polyphenyl Column, 450Å, 2.7 µm, 4.6 mm X 50 mm Columns contain 2.7 µm superficially-porous-silica particles having an average pore diameter of 450Å. The particles are functionalized with a proprietary polyphenyl bonding process that was specifically designed for LC or LC-MS analyses of intact IgG monoclonal antibodies and their fragments. Each batch is qualified using a gradient separation of the Waters mAb Subunit Standard (p/n: 186008927). Note p/n: 176004167 contains a BioResolve RP mAb Polyphenyl Column, 450Å, 2.7 µm, 4.6mm X 50mm, 1/pk with Intact mAb Mass Check Standard (p/n: 186006552) and mAb Subunit Standard (p/n: 186008927). Suggested Use: Intact protein and mAb subunit analysis, Protein Analysis, ADC characterization, AAV, Antibody Conjugates

Specifications
Separation Mode: Reversed Phase
Temperature Limits: 90 C
Maximum Pressure: 10000 psi (689 Bar)
Particle Size: 2.7 µm
Pore Size: 450 Å
QC Tested: Protein
System: HPLC, UHPLC, UPLC
USP Classification: L11
UNSPSC: 41115709
Brand: BioResolve
Product Type: Columns
Units per Package: 1 pk

Additional Information
BioResolve RP mAb Polyphenyl Column, 450Å, 2.7 µm, 4.6 mm X 50 mm, 1/pk Need a reversed-phase solution for intact and IdeS-ingested monoclonal antibodies? Then look no further than the BioResolve RP mAb Polyphenyl Column. This state-of-the-art LC-MS separation tool offers superficially porous silica particles that are functionalized by a novel polyphenyl bonding process that makes them specifically suited for the LC-MS or MS analyses of monoclonal antibodies. What’s more, this column can even be used on all UHPLC, UPLC or HPLC systems with minimal injection-to-injection carryover, which is perfect for scientists who are trying to develop methods. Take your monoclonal antibody analysis workflow to the next level by harnessing the power and functionality of the BioResolve RP mAb Polyphenyl Column. Paving a successful path toward MS adoption is prioritized by the BioResolve RP mAb Polyphenyl Column, as it offers features that make method transfer and validation much easier. For one, the combination of the novel polyphenyl bonding process and solid-core column technology enables you to achieve better resolution at higher flow rates. This is great for scientists who need to transfer methods from HPLC to UPLC systems to utilize those higher flow rates. Plus, the high-coverage bonding prevents carryover effects and increases low pH stability for longer overall column lifetimes. This is just one of the many ways that the BioResolve RP mAb Polyphenyl Column can greatly improve your separations and analyses. Speaking of separations, did you know that your analytical column can become fouled over time by particulate contaminants in the mobile phase stream? Although proper sample purification protocols removes many of the contaminants that may be lingering, they don’t account for any contaminants in the mobile phase stream that can become unstuck when increased flow rates are applied. To conquer this obstacle, we’re happy to provide the BioResolve RP mAb Polyphenyl VanGuard Cartridge . This guard cartridge seamlessly incorporates into your existing workflow to provide enhanced protection from particulate contaminants, plus it’s reusable and can be replaced with another genuine guard cartridge from Waters once it becomes worn. Why shop at Waters? For one, we offer the products, equipment and solutions needed for you to be successful in the lab. And in addition, we offer a vast selection of resources to improve your internal workflows and make your lab more efficient. Simply shop lab equipment to explore all of our offerings.

FAQ
What’s the Operating pH Range of the BioResolve RP mAb Polyphenyl Column? The BioResolve RP mAb Polyphenyl Column offers an operating pH range of 2 to 7 pH.