Agilent, 5190-2538, Agilent Bio SEC-5, 1000Å, 4.6 x 300 mm, 5 µm

Agilent Bio SEC-5, 1000Å, 4.6 x 300 mm, 5 µm. A size exclusion column for aggregate analysis of large biological molecules such as adeno associated virus and virus-like particles. Resolving range 15 kDa - 5 MDa.

Specifications:
Brand: Agilent Bio SEC-5
Hardware: SS
Inner Diameter (ID): 4.6 mm
LC Platform: Stainless Steel
Length: 300 mm
Maximum Temperature: 80 °C
Molecular Weight Lower Limit: 50000 Da
Molecular Weight Upper Limit: 7500000 Da
Part Number Application Domain: Biopharma
Part Number Application: Aggregate & Fragment AnalysisMonoclonal Antibodies (mABs)PeptidesProteins
Particle Size: 5 µm
Particle Type: Fully Porous
Phase: SEC
Pore Size: 1000 Å
Pressure Rating: 240 bar
Separation Mode: Size Exclusion (SEC)
Shipping Solvent: Phosphate Buffer
Technique: LC
UNSPSC Code: 41115711
pH Range: 2-8.5

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The Agilent Bio SEC-5 1000Å column is engineered for high-resolution size exclusion chromatography, designed to accurately separate and analyze biomolecules such as proteins, peptides, antibodies, and nucleic acids. Featuring a 4.6 x 300 mm dimension with a 5 micron particle size, this column offers excellent efficiency and reproducibility for both analytical and preparative applications. Its 1000 angstrom pore size supports the effective resolution of a broad molecular weight range, making it suitable for the characterization of aggregates, fragments, and protein complexes in biopharmaceutical research and quality control.

Ideal for use with aqueous mobile phases, this product is compatible with Agilent HPLC and UHPLC systems as well as a variety of other leading chromatography platforms. Typical usage scenarios include profiling of monoclonal antibodies, QC testing in pharmaceutical laboratories, and studying protein-protein interactions. The robust silica-based matrix with proprietary bonding provides high recovery and reliable lifetime even under demanding experimental conditions. For comprehensive workflows, it can be combined with Agilent’s line of detectors, sample preparation products, and compatible SEC standards, enabling precise and reproducible biomolecule separations for research and development laboratories focused on protein therapeutics and life science analysis.