Agilent, 653750-702, Agilent AdvanceBio Oligonucleotide, 2.1 x 150 mm, 2.7 µm

Agilent AdvanceBio Oligonucleotide, 2.1 x 150 mm, 2.7 µm. Reversed-phase HPLC column designed for high-resolution IP-RP separation of oligos. Scalable chemistry platform supports analytical through prep purification for optimal resolution, yield, purity.

Specifications:
Brand: AdvanceBio Oligonucleotide
Hardware: SS
Inner Diameter (ID): 2.1 mm
LC Platform: Stainless Steel
Length: 150 mm
Maximum Temperature: 65 °C
Part Number Application: Oligos
Part Number Application Domain: BiopharmaPharmaceutical
Particle Size: 2.7 µm
Particle Type: Superficially Porous
Phase: HPH-C18
Pore Size: 120 Å
Pressure Rating: 600 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LC & LC/MS
UNSPSC Code: 41115711
pH Range: 3-11

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Designed for high-resolution analysis and purification of synthetic oligonucleotides, this 2.1 x 150 mm column with a 2.7 micron particle size delivers exceptional performance for demanding research workflows. The advanced stationary phase provides excellent separation efficiency and reproducibility, minimizing sample loss and maximizing yield for both qualitative and quantitative studies. Optimized for use with ultra-high-performance liquid chromatography (UHPLC) and high-performance liquid chromatography (HPLC) systems, the column is particularly well-suited for laboratories working on therapeutic oligonucleotide development, quality control, and process monitoring. Common applications include the characterization of antisense oligonucleotides, siRNA, aptamers, and other nucleic acid-based biomolecules. The design supports compatibility with a wide range of mobile phases and harsh conditions often required for oligonucleotide separations, ensuring reliable and robust performance. It integrates seamlessly with Agilent 1200 Infinity and 1260 Infinity II LC systems, as well as other major chromatographic platforms. Researchers benefit from rapid method development, improved sensitivity, and consistent batch-to-batch performance. This column is part of the AdvanceBio portfolio, allowing easy method transfer and scalability within oligonucleotide analytical workflows. It serves as a crucial tool for biopharma, academic, and regulatory laboratories focused on nucleic acid research and product development.