Agilent, 655950-702, Agilent AdvanceBio Oligonucleotide, 4.6 x 100 mm, 2.7 µm

Agilent AdvanceBio Oligonucleotide, 4.6 x 100 mm, 2.7 µm. Reversed-phase HPLC column designed for high-resolution IP-RP separation of oligos. Scalable chemistry platform supports analytical through prep purification for optimal resolution, yield, purity.

Specifications:
Brand: AdvanceBio Oligonucleotide
Hardware: SS
Inner Diameter (ID): 4.6 mm
LC Platform: Stainless Steel
Length: 100 mm
Maximum Temperature: 65 °C
Part Number Application: Oligos
Part Number Application Domain: BiopharmaPharmaceutical
Particle Size: 2.7 µm
Particle Type: Superficially Porous
Phase: HPH-C18
Pore Size: 120 Å
Pressure Rating: 600 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LC & LC/MS
UNSPSC Code: 41115711
pH Range: 3-11

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Engineered for superior resolution and reliability, this 4.6 x 100 mm, 2.7 µm column is specifically designed for the separation and analysis of therapeutic oligonucleotides. Its advanced particle technology provides excellent efficiency and peak shape, crucial for the quantitation and characterization of antisense oligonucleotides, siRNA, and mRNA therapeutics. This column delivers robust performance across a wide range of oligonucleotide lengths and modifications, supporting demanding workflows in pharmaceutical development, quality control, and academic research.

Optimized for reversed-phase liquid chromatography, it ensures reproducible results in both analytical and semi-preparative scale studies. It is fully compatible with Agilent InfinityLab and 1100, 1200, and 1260 LC systems, as well as other major HPLC and UHPLC instruments, facilitating seamless integration into existing laboratory setups. The column is ideally suited for ion-pairing LC-MS analysis, enabling sensitive and reliable detection of complex oligonucleotide samples.

Researchers benefit from consistent batch-to-batch reproducibility and reduced carryover, which streamlines method development and validation processes. This product is supported by a full portfolio of related AdvanceBio columns and accessories, offering flexible solutions for diverse analytical challenges in nucleic acid research and biopharmaceutical development.