Agilent, 659750-702, Agilent AdvanceBio Oligonucleotide, 2.1 x 50 mm, 2.7 µm

Agilent AdvanceBio Oligonucleotide, 2.1 x 50 mm, 2.7 µm. Reversed-phase HPLC column designed for high-resolution IP-RP separation of oligos. Scalable chemistry platform supports analytical through prep purification for optimal resolution, yield, purity.

Specifications:
Brand: AdvanceBio Oligonucleotide
Hardware: SS
Inner Diameter (ID): 2.1 mm
LC Platform: Stainless Steel
Length: 50 mm
Maximum Temperature: 65 °C
Part Number Application: Oligos
Part Number Application Domain: BiopharmaPharmaceutical
Particle Size: 2.7 µm
Particle Type: Superficially Porous
Phase: HPH-C18
Pore Size: 120 Å
Pressure Rating: 600 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LC & LC/MS
UNSPSC Code: 41115711
pH Range: 3-11

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This high-performance column is engineered for the precise separation and analysis of oligonucleotides in research and biopharmaceutical development. Featuring a 2.1 x 50 mm dimension and 2.7 micron particle size, it offers excellent resolution and reproducibility for both short and long oligonucleotide sequences. The column's robust design enables reliable quantitation and purity assessment, making it ideal for applications in synthetic oligonucleotide QC, antisense and siRNA therapeutics development, and mRNA vaccine analysis. Optimized for compatibility with Agilent 1290 Infinity LC, 1260 Infinity II LC, and other UHPLC systems, it seamlessly integrates into existing analytical workflows. The column supports both ion-pair reversed-phase and anion-exchange chromatography methods, ensuring flexible use with a range of mobile phases and detection techniques such as UV and mass spectrometry. Its chemical stability ensures long lifetime, minimizing downtime and operating costs. As part of the AdvanceBio family, it can be paired with other Agilent sample preparation, detection, and characterization solutions to deliver comprehensive end-to-end workflows. This column is particularly suited for laboratories focused on advancing nucleic acid therapeutics, streamlining method development, and supporting regulatory compliance with reproducible, high-quality results.