Agilent, 695971-702, AdvanceBio Oligonucleotide, 4.6 x 100 mm, 4 µm

AdvanceBio Oligonucleotide, 4.6 x 100 mm, 4 µm. HPLC columns offer a high-quality, high-resolution IP-RP column chemistry platform that support analytical characterization through purification with method scale-up. The 4µm, 4.6 mm analytical scale column dimensions simplify method development calculations and optimization when translating your analytical method to larger inner diameter preparative dimensions for purification.

Specifications:
Brand: AdvanceBio Oligonucleotide
Guard Column: Yes
Hardware: SS
Inner Diameter (ID): 4.6 mm
LC Platform: HPLC
Length: 100 mm
Maximum Temperature: 65 °C
Particle Size: 4 µm
Particle Type: Superficially Porous
Phase: HPH-C18
Pore Size: 120 Å
Pressure Rating: 600 bar
Separation Mode: Reversed Phase
Shipping Solvent: Acetonitrile/Water
Technique: LC & LC/MS
pH Range: 3-11

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Optimized for high-resolution separation and analysis of synthetic oligonucleotides, this 4.6 x 100 mm, 4 micron column supports a broad range of applications in nucleic acid research and biopharmaceutical quality control. Engineered with proprietary particle technology, the column enables reliable and reproducible results for quantitative and qualitative assessment of oligonucleotide length, purity, and sequence-related variants. It is designed for use with both ion-pair reversed-phase and anion-exchange chromatography methods, facilitating versatility across various workflow needs.

Researchers can utilize this column for the analysis of DNA or RNA oligonucleotides, RNAi therapeutics, antisense drugs, and other modified nucleotide sequences. Its robust design supports operation at elevated pressures, making it compatible with modern UHPLC and HPLC systems, including Agilent 1200 Infinity Series and comparable platforms. The column integrates seamlessly with Agilent’s range of AdvanceBio buffers and calibration standards to maintain method consistency and regulatory compliance. Ideal for method development and routine monitoring, it delivers sharp peak resolution, high sensitivity, and excellent reproducibility, making it an essential tool for both research laboratories and biopharmaceutical production environments.