Agilent, PL1580-3250, AdvanceBio SEC 120 Å column, 1.9 µm, 4.6 x 150 mm

AdvanceBio SEC 120 Å column, 1.9 µm, 4.6 x 150 mm. A size exclusion column designed to improve resolution and provide faster separation of protein and peptide aggregates and fragments by UHPLC. Resolving range is 1-80 kDa.

Specifications:
Brand: AdvanceBio SEC
Guard Column: No
Hardware: SS
Inner Diameter (ID): 4.6 mm
LC Platform: Stainless Steel
Length: 150 mm
Maximum Temperature: 80 °C
Molecular Weight Lower Limit: 1000 Da
Molecular Weight Upper Limit: 80000 Da
Particle Size: 1.9 µm
Particle Type: Fully Porous
Phase: SEC
Pore Size: 120 Å
Pressure Rating: 620 bar
Separation Mode: Size Exclusion (SEC)
Shipping Solvent: Phosphate Buffer/0.02% Sodium azide
Technique: LC
UNSPSC Code: 41115709
pH Range: 2-8.5

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The Agilent AdvanceBio SEC 120 Angstrom, 1.9 micron, 4.6 x 150 mm column is engineered for high-resolution size exclusion chromatography of biomolecules, particularly proteins and mAbs. Its optimized pore size and particle technology enable precise separation of aggregates, monomers, and fragments, making it ideal for rigorous characterization and quantification tasks in pharmaceutical quality control, drug development, and protein research. The column’s high mechanical stability allows for rapid analysis without sacrificing resolution, supporting both routine workflows and demanding research applications.

This column provides reproducible performance across samples, facilitating direct comparison of size profiles and aggregation levels. Compatible with most UHPLC and HPLC systems, the column integrates seamlessly with Agilent’s InfinityLab LC Series and is fully supported by Agilent’s suite of AdvanceBio SEC standards and buffers for enhanced method reliability. Its robust construction ensures longevity and consistent results, contributing to lower operational costs over time. The AdvanceBio SEC 120 Angstrom column is a valuable tool for biopharmaceutical researchers, analytical scientists, and quality assurance laboratories seeking efficient molecular sizing, aggregate detection, and purity assessment in complex biological samples.