Agilent, PL1580-5302, AdvanceBio SEC 1000 Å, 2.7 µm, 4.6x300mm

AdvanceBio SEC 1000 Å, 2.7 µm, 4.6x300mm. A size exclusion column for aggregate analysis of large biological molecules such as VLPs and large oligonucleotides.

Specifications:
Brand: AdvanceBio SEC
Guard Column: No
Hardware: SS
Inner Diameter (ID): 4.6 mm
Length: 300 mm
Maximum Temperature: 80 °C
Molecular Weight Lower Limit: 15000 Da
Molecular Weight Upper Limit: 10 MDa
Particle Size: 2.7 µm
Particle Type: Fully Porous
Phase: SEC
Pore Size: 1000 Å
Pressure Rating: 400 bar
Separation Mode: Size Exclusion (SEC)
Shipping Solvent: Phosphate Buffer/0.02% Sodium azide
Storage Temp Conditions: Store at ambient temperature
pH Range: 2-8.5

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This high-performance size exclusion chromatography (SEC) column is engineered with a 1000 Å pore size and 2.7-micron particle technology, encapsulated in a robust 4.6 x 300 mm format. It enables precise molecular size characterization and quantitation of biotherapeutics, such as monoclonal antibodies, fusion proteins, and aggregates. Designed for superior resolution and batch-to-batch reproducibility, this column supports method development and quality control in both research and regulated environments.

Ideal for use in protein aggregation analysis, purity assessment, and comparability studies, it offers rapid run times and reliable separation profiles, promoting confidence in critical decision-making during drug development and manufacturing processes. The column demonstrates excellent compatibility with Agilent HPLC systems, including the InfinityLab series, and seamlessly integrates into existing analytical workflows. It also complements other chromatography techniques and is suitable for coupling with advanced detectors, such as multi-angle light scattering and mass spectrometry, for enhanced characterization.

Researchers and analysts will find this column especially beneficial in environments demanding robust performance, high throughput, and accurate characterization of biomolecules. Its durability and compatibility with common mobile phases streamline operation and ensure consistent, reproducible results across a wide variety of biopharmaceutical research and quality assurance applications.