Cytiva, FC5UASFP1AS, Supor™ Prime sterilizing grade filters

Supor™ Prime filter in large Kleenpak™ Spectrum capsule 127 mm (5 in.), 6100 cm² EFA, pre-sterilized
Supor™ Prime filters deliver high throughput for high concentration and high viscosity mAbs, proteins, and other challenging feeds.
• Increased product recovery due to high throughput
• Proven for feeds up to 220 g/L and 30 cP
• Low adsorption of active ingredients and excipients
• Scalable formats to grow with your process from clinical development to licensed drug manufacture
• Reduce burden of regulatory filing with comprehensive documentation package
The filtration of complex biotech drug formulations, such as high-concentration mAbs and encapsulated products, comes with unique challenges. These can include premature blocking due to high particulate loads, high differential pressures due to high viscosities, and risk of bacterial penetration. These challenges result in a need for larger filters or additional filters, leading to increased hold-up volume and higher product loss. Supor™ Prime sterilizing grade filters have been developed to meet these challenges. The high throughput of Supor™ Prime filters allows for reduced filtration area. By reducing the filter area, a smaller filter can be used resulting in increased product recovery per batch. Typical applications include: Filtration post ultrafiltration/diafiltration (UF/DF) Filtration of bulk drug substance Filtration of final formulation and fill In addition to cartridges for stainless steel housings, Supor™ Prime filters are offered in the new Kleenpak™ Spectrum capsule for single-use applications: High temperature and pressure rating to ensure robustness in challenging applications Easy to use vent and drain valve with gloved hands Vent/drain valve actuators decoupled from connector to reduce risk of tubing interference Supor™ Prime filters are offered in a range of filter formats and sizes, designed to support all development stages from benchtop testing to clinical trials and full scale good manufacturing practices (GMP) manufacture: Small Kleenpak Spectrum capsules and 47 mm discs to support filterability studies. Medium Kleenpak Spectrum capsules suitable for single-use applications. With a filter area of 240 cm² this format is typically used for volumes of > 1 L. Large Kleenpak Spectrum capsules suitable for single-use applications, available in four different areas ranging from 0.6 to 4 m² this format is typically used for volumes from 10 to > 100 L. Traditional cartridges ranging from 0.6 to 4 m² to support stainless steel applications. Contact a Cytiva associate today for more information on how we can test our Supor™ Prime filter on your high-concentration mAbs, protein, LNP, mRNA, or any other challenging feeds. Download our datasheet in the Related Documents section for more technical information.