Cytiva, ICL500CSSSIPH, iCELLis™ single-use fixed-bed bioreactor systems

iCELLis™ 500+ bioreactor system
The iCELLis™ bioreactor system is an automated, single-use, fixed-bed bioreactor that provides excellent cell growth conditions for adherent cells. Key features include:
• Cell culture process simplification, from vial to product
• Fully-integrated, single-use iCELLis™ 500+ bioreactor with disposable, pre-installed calibrated probes
• Unique waterfall system for optimal oxygenation and CO 2 stripping
• Compact high-cell-density, fixed-bed bioreactor providing a significant increase in volumetric productivity vs. traditional stirred tanks
• Predictable scalability from R&D to manufacturing
• Significant decrease in operational costs and capital investments vs. classical 2D flatware
• Full information about this product is available from the product datasheet.
The iCELLis™ bioreactor systems are available in two formats:
The iCELLis™ Nano system for process development and small-scale production (up to 4 m 2 ) The iCELLis™ 500+ system for industrial scale manufacturing (up to 500 m 2 ) The fixed-bed design of the iCELLis™ system makes it well-suited for industrialization of adherent cell processes and virus production for both gene therapy and vaccines, providing a large cell growth surface area while keeping the footprint very small. The iCELLis™ system accommodates up to 500 m 2 of growth area, which, when compared with available surfaces of multitray systems and roller bottles, corresponds to a huge reduction in volumes. The iCELLis™ 500+/500 m 2 system is equivalent to 794 cell stacks with 10 trays and 5,882 roller bottles at 850 cm 2 each. In addition to volume reduction, the use of a filled, fixed-bed in the iCELLis™ system enables high specific productivity. Wonderware is a trademark of Aveva Group Plc.