Thermo Fisher, I10189, Iodoacetamide Alkyne

Iodoacetamide Alkyne Conjugates prepared with the thiol-reactive alkyne, succinimidyl ester can be detected with an azide-containing molecule in a click chemistry reaction. Click chemistry describes a class of chemical reactions that use bio-orthogonal or biologically unique moities to label and detect a molecule of interest using a two-step procedure. The two-step reaction procedure involves a copper-catalyzed triazole formation of an azide and an alkyne. Click reactions have several characteristics: the reaction between the detection moieties is efficient; no extreme temperatures or solvents are required; the reaction product is stable; the components of the reaction are bioinert; and perhaps most importantly, no side reactions occur – the label and detection tags react selectively and specifically with one another. Unlike traditional chemical reactions utilizing succinimidyl esters or maleimides that target amines and sulfhydryls – functional groups that are not unique – click chemistry-labeled molecules can be applied to complex biological samples and be detected with unprecedented sensitivity due to extremely low background.
Chemical Reactivity: Thiol
Format: Solid
Label or Dye: Alkyne
Molecular Weight (g/mol): 223.
01 Da
Product Type: Iodoacetamide Alkyne
Quantity: 1 mg
Reactive Group: Iodoacetamide
Reactive Moiety: Alkyl Halide, Iodoacetamide
Shipping Condition: Room Temperature
Solubility: DMSO (Dimethylsulfoxide)
Label Type: Click Chemistry Label
Product Line: Molecular Probes™
Unit Size: Each