{"product_id":"abcam-ab101110","title":"Abcam, ab101110, Recombinant Human CBR4 protein","description":"\u003cp\u003eSize: 50µg \/ 250µg\u003cbr\u003e\nRecombinant Human CBR4 protein is a Human Full Length protein, in the 1 to 237 aa range, expressed in Escherichia coli, with \u0026gt;95%, suitable for SDS-PAGE, WB, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:WB, Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q8N4T8,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 1.16% Sodium chloride, 0.316% Tris HCl, 0.077% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CBR4 protein also known as Carbonyl Reductase 4 is an enzyme with a molecular mass of approximately 28 kDa. It functions as a NADPH-dependent oxidoreductase and plays a role in fatty acid metabolism. CBR4 is expressed in various tissues including the liver and the heart where it participates in several metabolic processes. The alternate name 'CBR4 SDS' is not typically used in scientific literature.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCBR4 acts in concert with other proteins as part of a heterotetrameric complex. Its primary role involves the reduction of carbonyl compounds which is essential in lipid synthesis and energy production. The enzyme contributes to the maintenance of cellular redox states and is involved in mitochondrial function thereby supporting the energy demands of cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe protein CBR4 integrates into the fatty acid biosynthetic and oxidative phosphorylation pathways. It processes carbonyl substrates in conjunction with other enzymes such as NADPH:quinone oxidoreductase. By facilitating these pathways CBR4 supports the cellular energy economy and the construction of cell membranes. Its activity interlinks with other mitochondrial enzymes enhancing the efficiency of mitochondrial respiration and lipid metabolism.\u003cbr\u003e\nThe CBR4 protein associates with disorders like non-alcoholic fatty liver disease and type 2 diabetes mellitus. The functional impairment of CBR4 may disrupt lipid metabolism leading to lipid accumulation and insulin resistance. CBR4's activity intersects with proteins like sterol regulatory element-binding proteins further connecting its role to metabolic syndrome and liver dysfunction.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843802222761,"sku":"ab101110","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab101110","provider":"Iright","version":"1.0","type":"link"}