{"product_id":"abcam-ab101318","title":"Abcam, ab101318, Anti-Zfp281\/ZNF281 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Zfp281\/ZNF281 antibody. Suitable for IP, WB and reacts with Mouse samples. Cited in 14 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:From Jan 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZfp281 also known as ZNF281 is a zinc finger protein that functions as a transcriptional regulator. It has a molecular weight of approximately 90 kDa. This protein is expressed in various tissues with notable presence in the liver heart and placenta. Zfp281 contains four C2H2-type zinc finger domains which facilitate its binding to specific DNA sequences allowing for the regulation of transcriptional activity. The protein plays significant roles in maintaining proper gene expression patterns during development and differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZfp281 influences the transcriptional landscape by acting as part of transcriptional regulatory complexes. It modulates the expression of genes involved in embryonic stem cell pluripotency and differentiation. Zfp281 interacts with other proteins such as Oct4 and Nanog which are key factors in maintaining stem cell properties. These interactions allow it to fine-tune cellular processes critical for the developmental fate of cells. Moreover Zfp281's role extends to the regulation of epithelial-to-mesenchymal transition affecting cell migration and invasion.\u003cbr\u003e\nPathways\u003cbr\u003e\nZfp281 engages in important regulatory networks like the Wnt\/β-catenin pathway which is integral to developmental signaling. In this context Zfp281 cooperates with proteins like TCF\/LEF family members to control target gene expression influencing cell fate decisions. It is also involved in the TGF-β signaling pathway where it collaborates with Smad proteins to regulate the transcriptional responses necessary for cellular differentiation and tissue homeostasis.\u003cbr\u003e\nZfp281 shows connections with cancer and fibrosis. In cancer aberrant expression of Zfp281 can lead to uncontrolled cell proliferation and metastasis often observed in breast and colorectal cancers. Its interaction with oncogenic factors like c-Myc further highlights its role in tumor progression. In fibrosis Zfp281 contributes to pathological tissue remodeling associated with excessive extracellular matrix production and scarring. The involvement of Zfp281 with fibrotic markers and TGF-β signaling suggests its potential as a therapeutic target to mitigate these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848648380585,"sku":"ab101318","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab101318","provider":"Iright","version":"1.0","type":"link"}