{"product_id":"abcam-ab102001","title":"Abcam, ab102001, Anti-Unrip antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nRabbit Polyclonal Unrip antibody. Suitable for ICC\/IF, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human STRAP aa 1-300.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human STRAP aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q9Y3F4\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUnrip also known as NRIP (nuclear receptor interaction protein) is a nuclear protein with a molecular mass of approximately 64 kDa. Researchers have identified its expression mainly in the nucleus across various tissues. Mechanically Unrip functions as a factor interacting with nuclear hormone receptors. It regulates transcriptional activity through direct contact with these receptors modulating gene expression. This interaction plays a role in how cells respond to specific hormones and signals.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUnrip contributes significantly to the regulation of gene expression by associating with other nuclear coregulators. It is part of a larger protein complex that includes importin beta and RIC1\/RAB1. This complex facilitates the proper localization and functioning of nuclear hormone receptors affecting the expression of target genes. Unrip’s involvement with such complexes illustrates its integral function in transcriptional regulation and cellular signaling pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nUnrip integrates into essential signaling networks particularly the nuclear receptor signaling and coactivator pathways. In these pathways Unrip modulates the activity of nuclear receptors like estrogen receptor alpha and glucocorticoid receptor affecting cellular responses to steroid hormones. Unrip interacts with proteins such as SRC-1 and GRIP1 within these pathways influencing gene expression profiles related to growth differentiation and metabolic processes.\u003cbr\u003e\nUnrip’s interactions impact conditions including cancer and hormone-related disorders. Its role in modulating estrogen and glucocorticoid receptors links it to breast cancer progression where these pathways are dysregulated. Additionally Unrip’s involvement in nuclear receptor signaling ties it to metabolic disorders like type 2 diabetes. Through the alteration of receptor pathways Unrip affects proteins like PPARγ demonstrating its relevance in disease mechanisms and therapeutic research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850099216553,"sku":"ab102001","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab102001","provider":"Iright","version":"1.0","type":"link"}