{"product_id":"abcam-ab103783","title":"Abcam, ab103783, Recombinant Human PFDN4 protein","description":"\u003cp\u003eSize: 50µg \/ 250µg\u003cbr\u003e\nRecombinant Human PFDN4 protein is a Human Full Length protein, in the 1 to 134 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q9NQP4,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.29% Sodium chloride, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe PFDN4 protein also known as Prefoldin Subunit 4 is part of a multi-subunit chaperone complex. The protein has a molecular mass of approximately 16 kDa and consists of several hydrophobic regions. Widely expressed in the cytoplasm PFDN4 interacts with actin and tubulin through its role in the prefoldin complex. It aids in the proper folding of these cytoskeletal proteins supporting overall cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIn cellular processes PFDN4 plays an important role as a component of the prefoldin complex. This complex is a heterohexameric assembly that supports the folding and transport of nascent polypeptide chains. Such activity is important for maintaining the stability and functionality of cytoskeletal proteins. By influencing protein conformation PFDN4 contributes to the structural integrity of cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nIn the protein biosynthesis context PFDN4 is involved in cytoskeleton organization and protein folding pathways. The prefoldin complex including PFDN4 facilitates the proper assembly and stabilization of tubulin which is significant for maintaining microtubule dynamics. Additionally PFDN4's interactions with chaperonin-containing TCP-1 (CCT) carry out essential roles in these pathways highlighting its contribution to cytoskeletal homeostasis.\u003cbr\u003e\nResearch links PFDN4 to conditions involving cytoskeletal defects such as certain neurodegenerative diseases and cancer. The malfunction of the prefoldin complex as seen in aberrant PFDN4 activity can disrupt cellular architecture and lead to disease progression. In particular PFDN4's relationship with proteins like tubulin and actin signifies that alterations in these interactions might contribute to oncogenesis and cancer metastasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844002730153,"sku":"ab103783","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab103783","provider":"Iright","version":"1.0","type":"link"}