{"product_id":"abcam-ab104437","title":"Abcam, ab104437, Anti-PGRMC2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal PGRMC2 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PGRMC2 aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human PGRMC2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O15173\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPGRMC2 also known as Membrane-Associated Progesterone Receptor Component 2 is a protein that plays several roles mechanically in the cell. This protein weighs approximately 22.5 kDa and exists across various tissues including liver adipose tissue and the central nervous system. It exists in cellular membranes where it may facilitate interaction with other cellular components. This specific positioning and distribution allow PGRMC2 to modulate various signaling pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPGRMC2 participates in multiple cellular processes related to cell survival and metabolism. It often functions as part of larger protein complexes and interacts with other proteins affecting mitochondrial function and steroid signaling. Its biological role includes influencing mitochondrial respiration and energy homeostasis critical processes in numerous cellular functions. Researchers have discovered that PGRMC2 interacts with heme impacting vital cellular and metabolic functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nPGRMC2 is active in steroid hormone signaling and cellular stress response pathways. It interacts with proteins like cytochrome P450 which is significant for the metabolism of various substances and heme oxygenase which regulates the degradation of heme. These interactions highlight PGRMC2's impact on vital pathways involved in maintaining cellular stability and response mechanisms.\u003cbr\u003e\nResearchers link PGRMC2 to metabolic conditions such as obesity and diabetes. It plays a role in lipid metabolism and energy balance both critical factors in the development of these conditions. Furthermore PGRMC2 interaction with insulin receptor substrates suggests a connection to insulin resistance a common feature of type II diabetes. Understanding PGRMC2's function and its related proteins offers potential insights into therapeutic targets for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853985239209,"sku":"ab104437","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab104437","provider":"Iright","version":"1.0","type":"link"}