{"product_id":"abcam-ab104483","title":"Abcam, ab104483, Recombinant Human RBP7 protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human RBP7 protein is a Human Full Length protein, in the 1 to 134 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q96R05,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 1.16% Sodium chloride, 0.316% Tris HCl, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRetinol Binding Protein 7 (RBP7) also known as CRBP4 belongs to the intracellular lipid-binding protein family. This protein has a molecular mass of approximately 15 kDa. RBP7 is expressed in various tissues including adipose tissue kidney and heart among others. It plays a role in shuttling retinoids intracellularly facilitating the transport and availability of retinol.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe function of RBP7 involves maintaining retinoid homeostasis by regulating the storage and release of retinol within cells. It does not appear to be part of a larger protein complex. RBP7 contributes to cellular differentiation and proliferation influencing processes related to cell growth. Its roles are important in maintaining tissue health especially relating to vision and epithelial integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nRBP7 is involved in the retinoic acid signaling pathway and contributes to lipid metabolism processes. Within these pathways it interacts indirectly with proteins such as retinaldehyde dehydrogenases that convert retinol into active forms. These pathways highlight the link RBP7 has with both metabolic and signaling functions showing its role in broader physiological contexts.\u003cbr\u003e\nAlterations in RBP7 expression or function associate with conditions like obesity and type 2 diabetes. These alterations may affect retinoid pathways and consequently influence energy homeostasis and insulin sensitivity. Through its interactions in these pathways RBP7 shares connections with proteins such as peroxisome proliferator-activated receptor gamma (PPARγ) which also plays a role in metabolic regulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844008202409,"sku":"ab104483","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab104483","provider":"Iright","version":"1.0","type":"link"}