{"product_id":"abcam-ab104635","title":"Abcam, ab104635, Recombinant Human MTHFS protein","description":"\u003cp\u003eSize: 100µg \/ 500µg\u003cbr\u003e\nRecombinant Human MTHFS protein is a Human Full Length protein, in the 1 to 203 aa range, expressed in Escherichia coli, with \u0026gt;95%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P49914,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 30% Glycerol (glycerin, glycerine), 1.16% Sodium chloride, 0.316% Tris HCl, 0.077% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMTHFS also known as methenyltetrahydrofolate synthetase is an enzyme that plays an important role in folate metabolism. It catalyzes the conversion of 5-formyltetrahydrofolate (5-formyl-THF) to 510-methenyltetrahydrofolate (510-methenyl-THF). MTHFS is a protein with a molecular mass of approximately 23 kDa. Expression occurs in various tissues with significant presence in the liver where folate-mediated one-carbon metabolism is important for various cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMTHFS impacts the cellular folate pool by regulating the balance of folate derivatives required for nucleotide biosynthesis and amino acid metabolism. It does not function as part of a larger protein complex but exerts its effects by modulating the availability of different folate forms. This balance is essential for the synthesis of purines and thymidylate key building blocks of DNA and RNA influencing cell proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nMTHFS plays a role in the folate cycle and the related one-carbon metabolism pathway. These pathways are critical for DNA synthesis and repair as well as methylation reactions. MTHFS interacts indirectly with enzymes such as dihydrofolate reductase (DHFR) and serine hydroxymethyltransferase (SHMT) which are also key players in these pathways. The precise regulation of these pathways reflects the importance of folate in maintaining cellular health and function.\u003cbr\u003e\nImpaired MTHFS function can lead to disruptions in folate metabolism contributing to the development of conditions such as neural tube defects and certain types of anemia. Research suggests a link between altered MTHFS activity and increased risk of these disorders. Its relationship with other proteins involved in folate metabolism such as folate receptor 1 (FOLR1) highlights the broader impact of disrupted folate metabolism on disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844018393257,"sku":"ab104635","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab104635","provider":"Iright","version":"1.0","type":"link"}