{"product_id":"abcam-ab10508","title":"Abcam, ab10508, Anti-KAT13C \/ NCOA2 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal KAT13C \/ NCOA2 antibody. Suitable for IHC-P, IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NCOA2 aa 1400 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human NCOA2 aa 1400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q15596,\u003cbr\u003e\nSpecificity:We have data to indicate that this antibody may not cross react with Xenopus laevis. However, this has not been conclusively tested and expression levels may vary in certain cell lines\/tissues.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antibodies were affinity purified using the peptide immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.1% Sodium azideConstituents: PBS, 1.815% Tris, 1.764% Sodium citrate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle, Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKAT13C also known as NCOA2 functions as a transcriptional coactivator involved in nuclear receptor-mediated gene expression. It has a molecular mass of approximately 170 kDa. This protein localizes in the nucleus where it binds with nuclear receptors to enhance transcriptional programming. It is expressed in various tissues including the brain heart and liver indicating its involvement in a diverse range of cellular activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKAT13C\/NCOA2 serves as part of a larger protein complex that regulates the expression of target genes following ligand binding to nuclear receptors. It acts as a scaffold protein recruiting additional transcriptional machinery to ensure efficient transcriptional activation. This role is critical for the regulation of hormone-responsive genes and in metabolism cell proliferation and differentiation processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nKAT13C\/NCOA2 plays a significant role in the steroid hormone receptor signaling pathway and the nuclear hormone receptor signaling pathway. It interacts with other proteins like p160 family members and the CREB-binding protein (CBP) facilitating coordinated gene expression involved in hormone response and metabolism. These interactions position KAT13C\/NCOA2 as an important player in fine-tuning cellular responses to external hormonal signals.\u003cbr\u003e\nKAT13C\/NCOA2 associates with prostate cancer and acute myeloid leukemia. In prostate cancer its interaction with androgen receptor signaling enhances cell proliferation. Meanwhile KAT13C\/NCOA2 amplifies gene expression involved in leukemia progression through its interaction with MLL fusion proteins which are implicated in the development of acute myeloid leukemia. These connections underline its role in disease states where abnormal signaling and transcriptional regulation occur.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854025838761,"sku":"ab10508","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab10508","provider":"Iright","version":"1.0","type":"link"}