{"product_id":"abcam-ab105194","title":"Abcam, ab105194, Anti-ZIP-5 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ZIP-5 antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human SLC39A5.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human SLC39A5. The exact immunogen used to generate this antibody is proprietary information.Q6ZMH5,\u003cbr\u003e\nSpecificity:ab105194 is predicted not to cross-react with other ZIP family members.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZIP-5 also known as SLC39A5 functions as a zinc transporter responsible for importing zinc ions into cells. This protein plays a critical role in maintaining zinc homeostasis allowing cells to efficiently uptake zinc from the extracellular environment. ZIP-5 has a mass of approximately 74 kDa. It is prominently expressed in tissues involved in zinc metabolism such as the pancreas liver and intestine. The location of its expression suggests its significant involvement in the regulation of zinc availability in important metabolic processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe ZIP-5 protein actively facilitates zinc uptake necessary for numerous cellular processes like enzymatic activity and gene expression. ZIP-5 does not act alone; it can interact with other proteins to ensure precise zinc distribution within cells. The function of ZIP-5 in cellular zinc homeostasis is essential for maintaining normal cell function and preventing zinc-related cytotoxicity which can disrupt various cellular activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nZIP-5 participates in the metallothionein and metal response element-binding transcription factor 1 (MTF-1) pathway. This pathway is important for zinc sensing and regulation. ZIP-5 operates in network with other zinc transporters such as ZIP4 to finely tune intracellular zinc levels. Through these interactions ZIP-5 adjusts cellular zinc levels during metabolic activities ensuring that zinc is available for necessary biochemical pathways like those that regulate cell growth differentiation and apoptosis.\u003cbr\u003e\nZIP-5 is implicated in conditions involving zinc deficiency or misregulation such as acrodermatitis enteropathica and chronic liver disease. For instance its altered expression may contribute to zinc malabsorption associated with such conditions. Additionally interactions between ZIP-5 and ZIP4 suggest an overlapping role in these disorders where proper functioning of both proteins is required to maintain zinc homeostasis. Understanding ZIP-5's role in these diseases aids in unraveling its potential as a therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854045958313,"sku":"ab105194","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab105194","provider":"Iright","version":"1.0","type":"link"}