{"product_id":"abcam-ab108418","title":"Abcam, ab108418, Anti-FES antibody [EPR3230(2)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal FES antibody. Suitable for WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3230(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe FES protein also known as Feline Sarcoma Oncogene is a cytoplasmic tyrosine kinase with a molecular mass of approximately 93 kDa. It plays a role in regulating processes like cell growth differentiation and survival. FES is mainly expressed in hematopoietic cells endothelial cells and some neural tissues. Its structure includes SH2 and SH3 domains allowing the protein to interact with other cellular components.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFES protein is involved in signal transduction pathways that control various physiological functions. It does not form part of any giant complexes rather it serves as a relay point for signals in cellular contexts. The kinase activity of FES is important for ensuring cellular processes such as actin remodeling an important process for cell movement and shape changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe FES protein participates in the RAS and MAPK signaling pathways. These pathways are important for transmitting extracellular signals that govern cell fate decisions. FES interacts with proteins such as GRB2 and SOS1 in these pathways to modulate downstream effects and enable effective response to cellular stimuli.\u003cbr\u003e\nAberrant FES signaling has links to cancer and inflammatory disorders. Dysregulation of FES can contribute to several types of cancer including leukemia due to its effect on cell proliferation and survival. In inflammation FES interaction with proteins like STAT3 may promote pathological inflammatory responses therefore implicating FES in diseases such as rheumatoid arthritis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850431582377,"sku":"ab108418","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab108418","provider":"Iright","version":"1.0","type":"link"}