{"product_id":"abcam-ab108603","title":"Abcam, ab108603, Anti-ENTPD5 antibody [EPR3784]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ENTPD5 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 7 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3784,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nENTPD5 also known as ectonucleoside triphosphate diphosphohydrolase 5 or NTPDase-5 primarily acts as an ER-resident glycoprotein that hydrolyzes nucleoside diphosphates into monophosphates. This enzyme weighs approximately 45 kDa. It is predominantly expressed in liver and pancreas tissues. Functionally ENTPD5 regulates cellular levels of UDP by converting GDP and its role in the re-glycosylation of proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis enzyme plays a role in protein folding and quality control within the endoplasmic reticulum. ENTPD5 influences the ER-associated degradation (ERAD) pathway which deals with the removal of misfolded proteins. The enzyme does interact with other proteins and complexes including calnexin and calreticulin chaperone systems suggesting its integration in glycan-processing machinery.\u003cbr\u003e\nPathways\u003cbr\u003e\nENTPD5 integrates into the protein glycosylation and turnover pathways. It links with the AKT\/mTOR signaling pathway by regulating the availability of UDP-GlcNAc a substrate for N-glycosylation of proteins. ENTPD5 relates to proteins like AKT and mTOR that are involved in protein synthesis cell growth and survival signaling pathways.\u003cbr\u003e\nENTPD5 has an association with cancer notably prostate cancer. The enzyme modulates the Warburg effect linked to the increased reglycosylation of proteins promoting tumor progression. It also connects to diabetes through its role in insulin signaling pathways where aberrant glycoprotein fragments may affect insulin receptor activity. Here ENTPD5 shows a connection to proteins involved in insulin signaling such as the insulin receptor.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844166733993,"sku":"ab108603","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab108603","provider":"Iright","version":"1.0","type":"link"}