{"product_id":"abcam-ab109240","title":"Abcam, ab109240, Anti-VCP antibody [EPR3307(2)]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-VCP antibody [EPR3307(2)] (ab109240) is a rabbit monoclonal antibody detecting VCP in  Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, IHC-P, ICC\/IF . Suitable for  Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 20 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3307(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, ICC\/IF, IHC-P, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-VCP antibody [EPR3307(2)] (ab109240) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of VCP?\u003cbr\u003e\nAnti-VCP [EPR3307(2)] (ab109240) specifically detects a band for VCP (UniProt: P55072) at a molecular weight of 89kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-VCP [EPR3307(2)] (ab109240) was first used in a scientific publication in 2011 and has been cited over 20 times in peer-reviewed journals.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR3307(2)] also available for your convenience: ab109240, Carrier free -\u003cbr\u003e\nab184905\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab204289\u003cbr\u003e\n, HRP -\u003cbr\u003e\nab204290\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle, Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe VCP protein also known as p97 or valosin-containing protein is a significant ATPase. It is involved mechanically in a range of cellular activities. VCP has a mass of approximately 97 kDa and is ubiquitously expressed in many tissues. It plays a role in protein homeostasis particularly in the degradation process of misfolded proteins via the ubiquitin-proteasome system. This protein comprises the D1 and D2 ATPase domains that are important for its unfolding activities.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe VCP protein operates as a vital part of cellular machinery and functions in various complexes. It assists in protein quality control by participating in processes such as ER-associated degradation (ERAD) where it retrotranslocates misfolded proteins from the endoplasmic reticulum for degradation. VCP also contributes to the regulation of endocytosis autophagy and cell cycle control. These functions are important in maintaining cellular integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nVCP integrates into cellular processes by engaging in essential pathways like the ubiquitin-proteasome system and autophagy. It associates with proteins such as UFD1 and NPL4 in these pathways illustrating its multifaceted role in cellular regulation. VCP's action is closely tied with the p97 protein complexes where it influences protein degradation and recycling thereby controlling protein turnover.\u003cbr\u003e\nThere are findings linking VCP to conditions such as inclusion body myopathy and Paget's disease of bone. Its malfunction due to mutations can trigger these diseases affecting muscle and bone tissues respectively. VCP's connection to other proteins like Parkin and Optineurin in these disorders highlights the protein's relevance in neurodegenerative and skeletal disease pathways emphasizing its pivotal role in maintaining cellular health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844135735465,"sku":"ab109240","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab109240","provider":"Iright","version":"1.0","type":"link"}