{"product_id":"abcam-ab109252","title":"Abcam, ab109252, Anti-S100 Calcium Binding Protein A13\/S100A13 antibody [EPR4510]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal S100 Calcium Binding Protein A13\/S100A13 antibody. Suitable for IHC-P, IP, WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR4510,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra), ICC\/IF, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nShipping conditions update: ambient shipping\u003cbr\u003e\nThis product will be delivered at ambient temperature instead of chilled – this is by design. Extensive stability testing confirmed that our products are suitable for shipment under ambient conditions and maintain expected quality.\u003cbr\u003e\nWhy the change?\u003cbr\u003e\nIt’s part of our commitment to more sustainable packaging solutions, with ambient deliveries using eco-friendly materials such as recyclable cardboard instead of polystyrene.\u003cbr\u003e\nWhat you need to know\u003cbr\u003e\nAmbient shipments come clearly marked on the delivery note.\u003cbr\u003e\nNo ice will be included in ambient shipments, but mixed orders (ambient and cold-chain items) will still arrive with ice packs to protect temperature-sensitive products.\u003cbr\u003e\nWarranty coverage remains fully valid, aligned with our validated shipping method.\u003cbr\u003e\nPlease store the product as per the datasheet instructions upon receipt.\u003cbr\u003e\nFind out more -\u003cbr\u003e\nhttps:\/\/www.abcam.com\/en-us\/support\/shipping-storage-support\/ambient-shipping\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Conditional Ambient, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nS100 Calcium Binding Protein A13 also known as S100A13 is a member of the S100 protein family and displays calcium-binding abilities usually binding two calcium ions. This small protein has a molecular mass of approximately 11 kDa. S100A13 is expressed in a variety of tissues including the heart brain and skeletal muscle. Its expression can be altered in different cellular conditions suggesting an adaptive role in diverse physiological contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nS100A13 influences several cellular processes related to growth and differentiation. This protein facilitates secretion of fibroblast growth factor 1 (FGF1) and interleukin-1 alpha (IL-1α) through a non-classical pathway. S100A13 does not function alone; it engages in complexes with other proteins to execute its roles. It often works together with S100A6 and calcyclin-binding protein in these secretory pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nS100A13 participates in the regulation of angiogenesis and inflammation. It is involved in the FGF signal transduction pathway by affecting the externalization of FGF1 an important player in angiogenesis. Additionally S100A13 contributes to inflammation-related processes. Its activity is linked to proteins such as p53 and FGF1 integrating it into wider cellular systems.\u003cbr\u003e\nS100A13 is implicated in cancer and chronic inflammatory conditions. Overexpression of S100A13 has links to tumor progression and aggressiveness suggesting a role in cancer. In chronic inflammation S100A13 associates with increased levels of inflammatory cytokines. It connects to proteins like FGF1 and IL-1α in these contexts linking it with pathophysiological mechanisms that underlie these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850243100841,"sku":"ab109252","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab109252","provider":"Iright","version":"1.0","type":"link"}