{"product_id":"abcam-ab109303","title":"Abcam, ab109303, Anti-GRK3 antibody [EPR2041(2)]","description":"\u003cp\u003eSize: 10µL-TRIAL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal GRK3 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR2041(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nG protein-coupled receptor kinase 3 (GRK3) also known as beta-adrenergic receptor kinase 2 (βARK2) is a serine\/threonine kinase with approximate mass of 80 kDa. It mainly phosphorylates activated G protein-coupled receptors (GPCRs) to initiate receptor desensitization. GRK3 is expressed in various tissues including the brain heart and immune cells where it regulates cellular response to external signals. By phosphorylating GPCRs GRK3 facilitates binding of arrestin proteins which inhibits further signaling and contributes to receptor internalization.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGRK3 influences signal transduction by modulating receptor sensitivity and turnover. It acts independently and as part of larger signaling complexes such as those involving β-arrestin proteins. This functional role affects numerous cellular processes including neurotransmitter release and immune responses. GRK3's activity and expression levels can modulate the intensity and duration of GPCR signaling affecting cellular intercommunication and adaptive responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nGRK3 plays a role in key signaling cascades like the adrenergic and chemokine pathways. It closely interacts with proteins like β-arrestin and GPCRs within these pathways guiding receptor trafficking and signal fidelity. The adrenergic pathway influences cardiovascular and central nervous system functions while the chemokine pathway impacts immune response and cell migration. By regulating these pathways GRK3 ensures balanced physiological and cellular responses.\u003cbr\u003e\nGRK3 is linked to neurological disorders and cardiovascular diseases. Dysregulation of GRK3 affects receptor signaling disrupting processes like synaptic transmission and heart rate regulation. Altered GRK3 expression is associated with conditions like bipolar disorder where it influences mood regulation. GRK3 also connects to adrenergic receptors in the context of heart failure affecting cardiac performance and response to stress signals. Understanding GRK3's role offers insights for therapeutic strategies targeting these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850369454249,"sku":"ab109303","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab109303","provider":"Iright","version":"1.0","type":"link"}