{"product_id":"abcam-ab109462","title":"Abcam, ab109462, Anti-PTS\/PTPS (phospho S19) antibody [EPR1517(2)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal PTS\/PTPS phospho S19 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR1517(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPTS\/PTPS also known as 6-pyruvoyltetrahydropterin synthase and sepiapterin reductase is an enzyme involved in the biosynthesis of tetrahydrobiopterin (BH4). Its molecular weight is approximately 23 kDa. The enzyme is expressed in various tissues including the liver kidney and brain. The enzyme catalyzes a step in the conversion of 78-dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin which is an important step in the BH4 production pathway.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPTS\/PTPS plays a significant role in neurotransmitter synthesis and regulation. BH4 acts as a cofactor for several hydroxylase enzymes these enzymes include phenylalanine hydroxylase tyrosine hydroxylase and tryptophan hydroxylase. PTS\/PTPS contributes to the production of neurotransmitters like dopamine serotonin and nitric oxide through its role in the biosynthesis of BH4. The protein functions as a part of a complex that includes other biosynthetic enzymes involved in the same pathway.\u003cbr\u003e\nPathways\u003cbr\u003e\nPTS\/PTPS is essential in the pathways involved in neurotransmitter metabolism and amino acid hydroxylation. The enzyme is intimately associated with the phenylalanine tyrosine and tryptophan metabolic pathways. In these pathways it interacts with proteins such as phenylalanine hydroxylase and nitric oxide synthase supporting the conversion of amino acids into critical neurotransmitters and molecules for physiological processes.\u003cbr\u003e\nPTS\/PTPS dysfunction links to neurological conditions and metabolic disorders. Mutations or deficiencies in the enzyme are associated with hyperphenylalaninemia due to BH4 deficiency impacting phenylalanine metabolism and leading to severe neurological symptoms. Another related disorder is dystonia a movement disorder where altered dopamine biosynthesis occurs. The interactions with enzymes like phenylalanine hydroxylase become disrupted further influencing the disease mechanisms and contributing to symptoms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850408841385,"sku":"ab109462","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab109462","provider":"Iright","version":"1.0","type":"link"}