{"product_id":"abcam-ab10983","title":"Abcam, ab10983, Anti-UCP1 antibody","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nAnti-UCP1 antibody (ab10983) is a rabbit polyclonal antibody detecting UCP1 in  Western Blot, IHC-P . Suitable for  Mouse, Rat . - Over 810 publications - Trusted since 2004\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human UCP1 aa 100-200 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P25874\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nStorage in frost-free freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.\u003cbr\u003e\nProduct Specifications\u003cbr\u003e\nAnti-UCP1 antibody (ab10983) is a rabbit polyclonal antibody and is validated for use in IHC-P, WB in mouse, rat samples.\u003cbr\u003e\nAnti-UCP1 antibody (ab10983) specifically detects UCP1 (UniProt ID: P25874; Molecular weight: 33kDa) and is sold in 50 µL selling sizes.\u003cbr\u003e\nQuality and Validation\u003cbr\u003e\nAbcam's high quality validation processes ensure Anti-UCP1 antibody (ab10983) has high sensitivity and specificity.\u003cbr\u003e\nAnti-UCP1 antibody (ab10983) has been cited over 814 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAnti-UCP1 antibody (ab10983) has 23 independent reviews from customers.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab10983 is affinity purified using the immunogenic peptide immobilized on agarose., Storage buffer-Preservative: 0.097% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUncoupling Protein 1 (UCP1) also known as thermogenin is an important protein found in the mitochondria of brown adipose tissue (BAT). It has a molecular mass of approximately 33 kDa. UCP1 functions as a mitochondrial carrier specifically involved in the process of proton transport across the inner mitochondrial membrane. It leads to the dissipation of the proton gradient producing heat instead of ATP. This process is called non-shivering thermogenesis. UCP1 is mainly expressed in brown adipose tissue an area important for heat production in mammals.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUCP1 plays an essential role in energy metabolism by activating thermogenesis in brown adipocytes. It does not form a larger multi-protein complex but acts as an independent protein facilitating a significant amount of heat production. By uncoupling oxidative phosphorylation UCP1 controls energy expenditure and is central to maintaining body temperature in cold environments. Its function regulates metabolic rate and prevents excess fat accumulation connecting with mechanisms involved in energy balance.\u003cbr\u003e\nPathways\u003cbr\u003e\nUCP1 is an integral component of the metabolic pathway for thermogenesis. The PPAR signaling pathway regulates its expression emphasizing its role in energy homeostasis. Additionally UCP1 interacts with proteins like PGC-1α an important regulator of energy metabolism and mitochondrial biogenesis. This interaction highlights UCP1's involvement in mitochondrial activity and adaptation to changes in temperature or diet linking it to important metabolic functions.\u003cbr\u003e\nUCP1 has been connected with obesity and metabolic syndrome. Its dysregulation can lead to impaired thermogenic responses and reduced metabolic rate contributing to metabolic disorders. UCP1 is related to leptin a protein that regulates appetite and energy balance which is impacted in cases of obesity. Understanding this relationship helps in exploring potential therapeutic targets for tackling obesity and related metabolic diseases by modulating UCP1 activity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844238987433,"sku":"ab10983","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab10983","provider":"Iright","version":"1.0","type":"link"}