{"product_id":"abcam-ab110012","title":"Abcam, ab110012, Anti-CYP4B1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal CYP4B1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Cytochrome P450 4B1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human Cytochrome P450 4B1. The exact immunogen used to generate this antibody is proprietary information.P13584\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CYP4B1 also known as Cytochrome P450 4B1 is an enzyme part of the Cytochrome P450 family which plays a significant role in metabolizing xenobiotics and endogenous compounds. It has a molecular mass of approximately 58 kDa. This enzyme is found in various tissues with high expression levels in the lung and liver tissues. The CYP4B1 catalyzes reactions involved in the oxidation of several substrates making it important for metabolic processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme acts mainly in the oxidation of fatty acids and other lipophilic compounds. It contributes to the activation and detoxification of xenobiotic substances. Although not a part of any large protein complex CYP4B1 works closely with its cofactors like NADPH-cytochrome P450 reductase to achieve its function. This interaction is essential for its role in the metabolic processes that maintain cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nCYP4B1 is involved in both the arachidonic acid metabolism and the eicosanoid synthesis pathways. These pathways are significant for producing signaling molecules that regulate inflammation and other physiological functions. CYP4B1 interacts with proteins such as ALOX5 (arachidonate 5-lipoxygenase) within these pathways contributing to the complex network that controls inflammatory responses and other related bioactivities.\u003cbr\u003e\nInvestigations have connected CYP4B1 to carcinogenesis and inflammatory lung diseases. Abnormal CYP4B1 function is often associated with cancer due to its role in metabolic activation of certain procarcinogens. It also shows a relationship with lung inflammation where its activity may influence disease progression. During these conditions alterations in CYP4B1 activity can modify the bioavailability of signaling molecules linking it to other proteins like COX-2 (Cyclooxygenase-2) that are central in inflammation-related pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848635830441,"sku":"ab110012","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab110012","provider":"Iright","version":"1.0","type":"link"}