{"product_id":"abcam-ab110259","title":"Abcam, ab110259, Anti-MTCO3 antibody [DA5BC4]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal MTCO3 antibody. Suitable for WB and reacts with Saccharomyces cerevisiae, Rat, Human, Mouse samples. Cited in 49 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:DA5BC4,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human, Saccharomyces cerevisiae,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-IgG fraction, Purification notes-ab110259 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation. Near homogeneity ab110259 was judged as near homogeneity by SDS-PAGE., Storage buffer-pH: 7.5Preservative: 0.02% Sodium azideConstituents: HEPES buffered saline, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMTCO3 also known as Cytochrome c oxidase subunit 3 is a protein component essential to mitochondrial function. It weighs approximately 30 kDa and plays a structural role in Cytochrome c oxidase which is part of the mitochondrial electron transport chain. Expression of MTCO3 occurs in the mitochondria of cells with high energy demand including muscle and heart tissue. This protein forms part of a larger complex that helps facilitate the transfer of electrons from cytochrome c to oxygen a critical step in cellular respiration.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMTCO3 interacts with other subunits within the Cytochrome c oxidase complex to ensure efficient electron transfer and reduction of oxygen to water. This enzyme complex is fundamental in maintaining the proton gradient across the mitochondrial membrane which drives ATP synthesis. As part of this complex MTCO3 helps in coupling electron transfer with proton translocation therefore playing an important role in energy production within cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nMTCO3 is integral to the oxidative phosphorylation pathway which is an important process in cellular energy production. This pathway enables ATP generation through the mitochondrial electron transport chain critical for cell survival and function. MTCO3 collaborates with proteins like MTCO1 and MTCO2 which also belong to the Cytochrome c oxidase complex in these biological processes.\u003cbr\u003e\nMTCO3 relates to conditions such as mitochondrial myopathy and Leigh syndrome. These are genetic disorders affecting mitochondrial energy production often due to mutations affecting components of the electron transport chain. MTCO3 has connections to these diseases through its interaction with other electron transport chain constituents such as MTND1 and ATP6 which are also implicated in mitochondrial disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855400292521,"sku":"ab110259","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab110259","provider":"Iright","version":"1.0","type":"link"}