{"product_id":"abcam-ab111121","title":"Abcam, ab111121, Anti-ALK-7 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ALK-7 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human, African green monkey samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human ACVR1C.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, African green monkey,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ACVR1C. The exact immunogen used to generate this antibody is proprietary information.Q8NER5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab111121 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nALK-7 also known as Activin receptor-like kinase 7 is a type I receptor serine\/threonine kinase. It has a molecular mass of approximately 58 kDa. ALK-7 is primarily expressed in the central nervous system pancreatic islets and adipose tissue. This protein plays a mechanical role as a receptor that binds to ligands like Nodal which initiates signaling through phosphorylation events essential for cellular communication and regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nALK-7 participates in the regulation of metabolic processes. It functions by forming a receptor complex with type II receptors upon ligand binding transmitting signals that modulate cellular responses. ALK-7's signaling is important in maintaining glucose homeostasis and energy balance within tissues. Additionally the activity of ALK-7 influences the differentiation of neural cells and the development of adipose tissue illustrating its multifaceted biological roles.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe signaling of ALK-7 integrates into the TGF-beta\/Activin signaling pathway and the Nodal signaling pathway. Within these pathways it associates functionally with proteins such as SMAD2\/3 which facilitate the transmission of extracellular signals to the nucleus resulting in gene expression changes. These pathways are significant for developmental processes and cellular metabolism regulation where ALK-7 contributes to signal transduction necessary for physiological adaptations.\u003cbr\u003e\nALK-7 has associations with metabolic syndromes like type 2 diabetes and obesity. Altered ALK-7 signaling affects insulin sensitivity and glucose metabolism linking it to the pathophysiology of these conditions. Furthermore its interaction with Nodal and other factors in related pathways suggests a potential therapeutic target for mitigating metabolic dysfunctions associated with these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848591003817,"sku":"ab111121","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab111121","provider":"Iright","version":"1.0","type":"link"}