{"product_id":"abcam-ab111960","title":"Abcam, ab111960, Anti-Orai1 antibody [EPR3394(2)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Orai1 antibody. Suitable for WB and reacts with Human samples. Cited in 9 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3394(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOrai1 also known as CRACM1 is an important protein that forms part of the calcium release-activated calcium (CRAC) channels. These channels are essential for calcium ion flow across cell membranes. Orai1 weighs about 33 kDa and plays an integral role in cellular calcium homeostasis. This protein is expressed ubiquitously but it is found in high levels in excitable cells like T-cells where calcium signaling is important for activation and function. The Orai1 channel structure includes six transmembrane segments and works specifically with calcium-specific pore formation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOrai1 is a critical component of the store-operated calcium entry (SOCE) mechanism which maintains cellular calcium levels after depletion. Orai1 partners with stromal interaction molecule 1 (STIM1) to form the functional CRAC channel complex. Upon calcium store depletion STIM1 senses this change and interacts with Orai1 triggering calcium influx. This process is important in activating various cellular responses and promoting the function of immune cells among others.\u003cbr\u003e\nPathways\u003cbr\u003e\nOrai1 is a significant player in the calcium signaling pathway and the immune response pathway. Through its role in maintaining cellular calcium levels it influences the activation of various downstream signaling events including those involving calcineurin and nuclear factor of activated T-cells (NFAT). These interactions highlight the protein's importance in transcriptional regulation and immune cell activation highlighting its connection to proteins like STIM1 and NFAT.\u003cbr\u003e\nOrai1 disruption relates to immune dysfunction and autoimmune diseases like severe combined immunodeficiency (SCID) and rheumatoid arthritis. Mutations in Orai1 lead to impaired CRAC channel function and compromised calcium homeostasis affecting immune cell function. Furthermore the aberrant expression or function of Orai1 and its partner STIM1 associates with these disorders providing potential targets for therapeutic CRAC channel inhibitors aimed to restore normal signaling and immune function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850278785193,"sku":"ab111960","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab111960","provider":"Iright","version":"1.0","type":"link"}