{"product_id":"abcam-ab113137","title":"Abcam, ab113137, Recombinant Human PFDN5 protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human PFDN5 protein is a Human Full Length protein, in the 1 to 154 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q99471,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Prefoldin Subunit 5 (PFDN5) also known as PFD5 or MKBP is a protein that forms part of the prefoldin complex. This protein which has a mass of around 15.7 kDa plays an important mechanical role in delivering nascent polypeptide chains to the chaperonin complex for proper folding. PFDN5 is expressed widely across various tissues with notable expression in the brain and testis. Its involvement in such fundamental processes suggests it supports maintaining cellular stability and homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPFDN5 contributes to the assembly and stabilization of cytoskeletal structures by participating in tubulin folding processes. It functions as a component of the prefoldin complex a hexameric molecular chaperone. Through its action PFDN5 assists in the folding and assembly of cytoskeletal proteins such as actin and tubulin ensuring proper cellular architecture and transport functions. The protein’s interaction within the complex highlights its support in cellular dynamics and structural maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nPFDN5 integrates into important cellular pathways related to protein folding and cytoskeletal assembly. It participates prominently in the tubulin folding pathway which is essential for microtubule formation. In this context PFDN5 interacts significantly with chaperonin-containing T-complex protein 1 (CCT) to facilitate the assembly of tubulin monomers into functional microtubules. These interactions highlight PFDN5’s role in maintaining cellular integrity and facilitating intracellular transport mechanisms.\u003cbr\u003e\nPFDN5 presents associations with certain cancers particularly glioma. Altered expression or function of PFDN5 can disrupt normal cytoskeletal processes contributing to the irregular cell proliferation observed in gliomas. It has shown interactions with proteins like CCT2 in such pathological conditions. Furthermore PFDN5’s involvement in neurodegenerative processes links it to diseases like amyotrophic lateral sclerosis (ALS). In these contexts PFDN5 might influence disease progression through its impact on protein stability and cellular architecture.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844016099497,"sku":"ab113137","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab113137","provider":"Iright","version":"1.0","type":"link"}