{"product_id":"abcam-ab113239","title":"Abcam, ab113239, Anti-Eph receptor A6 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal Eph receptor A6 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human, African green monkey samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human EPHA6 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, African green monkey,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human EPHA6 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9UF33\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEph receptor A6 also known as EphA6 acts as a receptor tyrosine kinase which belongs to the ephrin receptor subfamily. Its structure involves a mass of approximately 110 kDa. EphA6 is expressed in various tissues with notably high expression in the brain. It plays a mechanical role by binding ephrin ligands which leads to receptor activation and downstream signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEphrin-Eph receptor interactions regulate processes like cell adhesion migration and development with EphA6 influencing neural development and plasticity. It does not form a complex on its own but interacts with ephrin ligands to initiate cellular responses. These functions are important for maintaining cellular architecture and communication during development.\u003cbr\u003e\nPathways\u003cbr\u003e\nEphA6 participates in the Ephrin signaling pathway engaging in complex interactions to mediate developmental processes. This receptor also involves itself in the neural development pathway. Proteins like EphA2 and ephrin-A1 frequently interact with EphA6 within these pathways facilitating various signaling cascades that are significant for cellular architecture.\u003cbr\u003e\nAbnormal expression or function of EphA6 has been associated with neurodegenerative disorders like Alzheimer's disease. Changes in EphA6 participate in disruption of synaptic connections. Within cancer biology EphA6 has been implicated in tumor progression and metastasis. In these contexts it may interact with other proteins such as EGFR influencing cellular behaviors related to malignancy.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854223823017,"sku":"ab113239","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab113239","provider":"Iright","version":"1.0","type":"link"}