{"product_id":"abcam-ab11427","title":"Abcam, ab11427, Anti-Parvalbumin antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nAnti-Parvalbumin antibody (ab11427) is a rabbit polyclonal antibody detecting Parvalbumin in  IHC-P, ICC\/IF . Suitable for  Human, Rat . - Over 280 publications - Trusted since 2004\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Native Full Length Protein corresponding to Rat Pvalb.P02625\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-Parvalbumin antibody (ab11427) is a rabbit polyclonal antibody and is validated for use in ICC\/IF, IHC-P in human, mouse, rat samples.\u003cbr\u003e\nAnti-Parvalbumin antibody (ab11427) has been cited over 285 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAbcam's high quality validation processes ensure Anti-Parvalbumin antibody (ab11427) has high sensitivity and specificity.\u003cbr\u003e\nAnti-Parvalbumin antibody (ab11427) has 30 independent reviews from customers.\u003cbr\u003e\nAnti-Parvalbumin antibody (ab11427) specifically detects Parvalbumin (UniProt ID: P20472; Molecular weight: 12kDa) and is sold in 50 µg selling sizes.\u003cbr\u003e\nParvalbumin is a calcium-binding protein predominantly found in fast-spiking interneurons in the brain. It plays a critical role in regulating intracellular calcium levels and neurotransmission. Altered parvalbumin expression is associated with several neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorders, where it affects neuronal excitability and synaptic function.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.5Preservative: 0.1% Sodium azideConstituents: 2% BSA, 1.62% Sodium phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nParvalbumin sometimes referred to as PV is a calcium-binding protein approximately 12 kDa in size. It is recognized for its roles in muscle and neuronal tissues. Within the nervous system parvalbumin is prominently expressed in fast-spiking GABAergic interneurons while in muscle tissues it is present in fast-twitch muscle fibers. Other popular descriptors include anti PV and parvalbumins. These proteins play important roles in the regulation of cellular calcium levels.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nParvalbumin helps modulate calcium ion concentration which is key in muscle relaxation and neurotransmission. It acts by buffering calcium ions and is not part of a larger protein complex. By impacting calcium transients parvalbumin affects processes like synaptic plasticity and the rapid contractions of muscle fibers. This is especially significant in the brain where rapid neuronal firing is needed and in muscles where quick recovery is essential.\u003cbr\u003e\nPathways\u003cbr\u003e\nParvalbumin is intimately linked with calcium signaling pathways as well as the regulation of muscle contraction. It ensures proper calcium ion homeostasis thereby aiding muscle relaxation after contraction. In the nervous system calbindin proteins parallel some of parvalbumin's functions participating in calcium ion buffering and modulation of neuron excitability. The balanced action of these proteins helps maintain cellular functions in both neurons and muscles.\u003cbr\u003e\nInsufficient parvalbumin expression may link to epilepsy and schizophrenia. Deficits in this protein could interfere with normal neurotransmission and muscle relaxation cycles. Parvalbumin deficiency influences neurotransmitter release affecting synaptic transmission which may exacerbate symptoms in these conditions. In disease mechanisms proteins such as calbindin may indirectly relate with parvalbumin showing similar patterns of dysregulation and compensating for its absence in calcium handling.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855747109033,"sku":"ab11427","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab11427","provider":"Iright","version":"1.0","type":"link"}