{"product_id":"abcam-ab116195","title":"Abcam, ab116195, Recombinant Human Elongin-C protein","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRecombinant Human Elongin-C protein is a Human Full Length protein, in the 1 to 112 aa range, expressed in Escherichia coli, with \u0026gt;90%, suitable for SDS-PAGE, Mass Spec.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q15369,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPreviously labelled as TCEB1.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nElongin C also known as Elongin BC is a small protein with a mass of approximately 11 kDa. This protein is part of the Elongin complex which includes Elongin B and Elongin A. It is widely expressed in various tissues facilitating its role in transcriptional regulation. Elongin C works mechanically by forming a complex with Elongin B to elongate RNA polymerase II transcription and it acts as an adaptor in various cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nElongin C participates in stabilizing the association of Elongin A with RNA polymerase II. It is an essential component of the transcription elongation complex influencing the transcriptional activity of genes. By forming a complex with Elongin B it propels the transcription process forward particularly in response to signals that regulate transcription elongation. Elongin C also connects with the cullin-RING E3 ubiquitin ligase (CRL) complex contributing to protein degradation pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nElongin C plays a significant role in the ubiquitin-proteasome system which targets proteins for degradation. It functions alongside Elongin A and Elongin B in this pathway where these components coordinate to control protein levels in the cell. Elongin C associates with the VHL (Von Hippel-Lindau) tumor suppressor protein in the pathway responsible for hypoxia-inducible factor (HIF) degradation therefore influencing cellular responses to oxygen availability.\u003cbr\u003e\nAlterations in Elongin C are implicated in cancer and von Hippel-Lindau disease. The disruption of its function can affect the stability and degradation of HIF leading to aberrant cellular proliferation and tumor progression. Elongin C through interaction with VHL highlights its importance in managing proper cell growth and differentiation underpinning its potential role in developing therapeutic targets for cancer treatment.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844019933353,"sku":"ab116195","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab116195","provider":"Iright","version":"1.0","type":"link"}