{"product_id":"abcam-ab118572","title":"Abcam, ab118572, Anti-Ezrin \/ Radixin \/ Moesin antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal Radixin\/RDX antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human EZR conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human EZR conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P15311\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle, Store undiluted\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEzrin Radixin and Moesin collectively known as the ERM proteins serve as vital linkers between the plasma membrane and the actin cytoskeleton. Ezrin is particularly recognized for its function as a structural organizer within cells facilitating various membrane-cytoskeletal interactions. The ezrin peptide has a mass of approximately 69 kDa. These ERM proteins show expression across diverse tissues but concentrate in epithelial cells supporting cellular shape and surface structure. They act mechanistically by binding to plasma membrane proteins and the cytoskeleton anchoring the membrane to the actin filaments.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEzrin Radixin and Moesin play important roles in cellular morphology motility and adhesion impacting signal transduction processes. These proteins do not operate singularly; they form and function as part of larger complexes that regulate cell surface structures and dynamics. ERM proteins dynamically associate and dissociate from cellular membranes facilitating the assembly and disassembly of membrane domains. By regulating microvilli structure their activity directly affects processes like nutrient absorption and pathogen defense in epithelial cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nEzrin Radixin and Moesin participate in organizing various signal transduction pathways notably the Rho and Ras signaling pathways. These pathways influence cell motility proliferation and survival. The ERM proteins interact with regulatory molecules such as Rho GTPases and integrate signals from membrane receptors to coordinate cytoskeletal reorganization. Their association with the Ras pathway helps modulate growth factor signaling linking membrane dynamics to cell growth and differentiation processes.\u003cbr\u003e\nAlterations in Ezrin and related proteins contribute to cancer progression and neurodegenerative conditions. Ezrin through its interactions with proteins like CD44 promotes metastatic behavior in cancer cells by enhancing cellular invasiveness and motility. In neurodegenerative disorders disruptions in ERM protein function can impair cellular signaling pathways contributing to disease pathology. Understanding the precise molecular interactions and downstream effects of Ezrin Radixin and Moesin provides insights into potential therapeutic targets for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848591102121,"sku":"ab118572","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab118572","provider":"Iright","version":"1.0","type":"link"}