{"product_id":"abcam-ab120058","title":"Abcam, ab120058, Forskolin, Adenylyl cyclase activator","description":"\u003cp\u003eSize: 5mg \/ 10mg \/ 50mg \/ 100mg\u003cbr\u003e\nCell-permeable activator of adenylyl cyclase. Interacts directly with the catalytic subunit of the enzyme to increase intracellular cAMP levels. MW 410.5. - Positive inotropic, platelet antiaggregatory and antihypertensive actions in vivo. - 3D Growth matrix component used in liver organoid generation. - Available in different sizes to fit your experimental needs.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:66575-29-9,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nSource:Coleus forskohlii,\u003cbr\u003e\nMolecular weight:410.5 Da,\u003cbr\u003e\nMolecular formula:C22H34O7,\u003cbr\u003e\nPubChem:47936,\u003cbr\u003e\nNature:Native,\u003cbr\u003e\nBiochemical name:Forskolin,\u003cbr\u003e\nBiological description:Cell-permeable activator of adenylyl cyclase. Interacts directly with the catalytic subunit of the enzyme to increase intracellular cAMP levels. Positive inotropic, platelet antiaggregatory and antihypertensive actions in vivo. 3D Growth matrix component used in liver organoid generation.,\u003cbr\u003e\nCanonical smiles:CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O,\u003cbr\u003e\nIsomeric smiles:CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O,\u003cbr\u003e\nInChi:InChI=1S\/C22H34O7\/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19\/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3\/t13-,15-,16-,17-,19-,20-,21+,22-\/m0\/s1,\u003cbr\u003e\nInChiKey:OHCQJHSOBUTRHG-KGGHGJDLSA-N,\u003cbr\u003e\nIUPAC Name:[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nCheck out our range of Adenylyl cyclase activator biochemicals\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAC1 has connections to conditions like depression and addiction where dysregulation of cAMP signaling is observed. Altered activity of AC1 can affect other proteins such as protein kinase A which plays a role in emotional and reward responses. Understanding the function of AC1 in these conditions aids in exploring potential therapeutic targets for neuropsychiatric and neurodegenerative diseases.\u003cbr\u003e\nPathways\u003cbr\u003e\nAdenylate cyclase activity is integral in the cAMP signaling pathway where it mediates the effects of neurotransmitters and hormones. This pathway is important for processes such as learning and memory where cAMP acts as an important mediator. AC1 activity is linked to proteins involved in the Calcium\/Calmodulin-dependent protein kinase pathway providing a bridge between calcium signaling and cAMP production which influences synaptic plasticity and neurocognitive functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAdenylate cyclases like AC1 play critical roles in signal transduction by regulating the intracellular concentration of cAMP a second messenger involved in numerous cellular processes. AC1 is part of a complex including G-protein coupled receptors which regulate its activity. The presence of AC1 in the brain suggests its involvement in neural signaling and neuroplasticity contributing to the modulation of synaptic transmission and the function of neuronal networks.\u003cbr\u003e\nAdenylate cyclase 1 (AC1) also known as adenylate cyclase is an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP) in response to various signaling molecules. This enzyme has a molecular mass of approximately 130 kDa. AC1 is localized mainly in neurons of the central nervous system. It acts as an adenylate cyclase activator responding to signals and modulating the downstream effects via cAMP production. Forskolin is a well-known pharmacological activator of adenylate cyclases including AC1 which can elevate intracellular cAMP levels.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847396217001,"sku":"ab120058","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab120058","provider":"Iright","version":"1.0","type":"link"}