{"product_id":"abcam-ab120152","title":"Abcam, ab120152, AF-DX 116 (Otenzepad), M2 antagonist","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 421.5 Da, Purity \u0026gt;99%. Selective M2 receptor antagonist. Achieve your results faster with highly validated, pure and trusted compounds.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:102394-31-0,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:421.5 Da,\u003cbr\u003e\nMolecular formula:C24H31N5O2,\u003cbr\u003e\nPubChem:107867,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 25 mM,\u003cbr\u003e\nBiochemical name:Otenzepad,\u003cbr\u003e\nBiological description:Selective M2 receptor antagonist.,\u003cbr\u003e\nCanonical smiles:CCN(CC)CC1CCCCN1CC(=O)N2C3=CC=CC=C3C(=O)NC4=C2N=CC=C4,\u003cbr\u003e\nInChi:InChI=1S\/C24H31N5O2\/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29\/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31),\u003cbr\u003e\nInChiKey:UBRKDAVQCKZSPO-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:11-[2-[2-(diethylaminomethyl)piperidin-1-yl]acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMuscarinic Acetylcholine Receptor 2 (M2) also known as CHRM2 is a G protein-coupled receptor (GPCR) with a molecular mass of about 66 kDa. This receptor is predominantly expressed in cardiac tissue particularly in the atria and plays a fundamental role in the parasympathetic nervous system by mediating the effects of acetylcholine. M2 receptors participate in negative feedback control by inhibiting adenylate cyclase which reduces the conversion of ATP to cAMP affecting heart rate and contractility. These receptors are an important target for anti-muscarinic agents like otenzepad and AF-DX 116 which inhibit the receptor's activity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMuscarinic acetylcholine receptors perform diverse functions participating in the regulation of autonomic nervous system responses. M2 receptors are not part of a large protein complex but function closely with other GPCRs to maintain homeostasis. They modulate the activity of various ion channels contributing to their role in cardiac physiological processes. Anti-muscarinic antibodies can specifically target M2 for therapeutic interventions which further helps in dissecting their biological functionality.\u003cbr\u003e\nPathways\u003cbr\u003e\nM2 receptors play essential roles in both the autonomic nervous system and the cardiovascular system. They are involved in the cholinergic signaling pathway which modulates heart rate by influencing ion channel activity and reducing intracellular cAMP levels. Their interaction with proteins like G-proteins and ion channels such as Kir3.1 underlines their importance in these pathways. M2 muscarinic receptors are closely linked with other muscarinic receptors showing a collaborative action in signaling cascades.\u003cbr\u003e\nM2 receptors have connections with cardiovascular diseases and certain neurological disorders. Alterations in M2 receptor function or expression can lead to conditions like bradycardia where the heart rate is abnormally slow and are also implicated in cognitive disorders linked to cholinergic dysfunction. The receptor's interaction with other muscarinic receptors like M1 and M4 further ties it to these pathologies amplifying its relevance in understanding complex diseases. Anti-muscarinic antibodies targeting M2 can modulate these interactions offering potential therapeutic benefits.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847425839273,"sku":"ab120152","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab120152","provider":"Iright","version":"1.0","type":"link"}