{"product_id":"abcam-ab120181","title":"Abcam, ab120181, Kisspeptin-13 (4-13) (human) (KiSS-1 (112-121)), AXOR12 agonist","description":"\u003cp\u003eSize: 1mg\u003cbr\u003e\nMW 1302.4 Da, Purity \u0026gt;95%. Achieve your results faster with highly validated, pure and trusted compounds.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:374675-21-5,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:1302.4 Da,\u003cbr\u003e\nMolecular formula:C63H83N17O14,\u003cbr\u003e\nPubChem:25240297,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water,\u003cbr\u003e\nBiochemical name:Kisspeptin-10,\u003cbr\u003e\nCanonical smiles:CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)C(CO)NC(=O)C(CC(=O)N)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC(=O)N)NC(=O)C(CC5=CC=C(C=C5)O)N,\u003cbr\u003e\nIsomeric smiles:CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC5=CC=C(C=C5)O)N,\u003cbr\u003e\nInChi:InChI=1S\/C63H83N17O14\/c1-34(2)24-45(58(90)74-43(18-11-23-70-63(68)69)57(89)75-44(54(67)86)26-35-12-5-3-6-13-35)73-53(85)32-72-56(88)46(27-36-14-7-4-8-15-36)77-62(94)50(33-81)80-61(93)49(30-52(66)84)79-59(91)47(28-38-31-71-42-17-10-9-16-40(38)42)78-60(92)48(29-51(65)83)76-55(87)41(64)25-37-19-21-39(82)22-20-37\/h3-10,12-17,19-22,31,34,41,43-50,71,81-82H,11,18,23-30,32-33,64H2,1-2H3,(H2,65,83)(H2,66,84)(H2,67,86)(H,72,88)(H,73,85)(H,74,90)(H,75,89)(H,76,87)(H,77,94)(H,78,92)(H,79,91)(H,80,93)(H4,68,69,70)\/t41-,43-,44-,45-,46-,47-,48-,49-,50-\/m0\/s1,\u003cbr\u003e\nInChiKey:RITKWYDZSSQNJI-INXYWQKQSA-N,\u003cbr\u003e\nIUPAC Name:(2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]butanediamide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe NPFF1 receptor NPFF2 receptor and GPR54 also known as the Kisspeptin receptor belong to the G protein-coupled receptor family. These receptors mechanically function by binding to neuropeptides such as neuropeptide FF and Kisspeptin resulting in signal transduction that affects various cellular responses. GPR54 the Kisspeptin receptor has a molecular mass of about 42 to 44 kDa. The NPFF1 and NPFF2 receptors are broadly expressed in the central nervous system while GPR54 is mainly found in the hypothalamus pituitary and reproductive organs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese receptors play significant roles in maintaining homeostasis and reproductive functions by mediating major neurophysiological processes. GPR54 coupled with Kisspeptin is part of an important neuroendocrine complex that stimulates the release of gonadotropin-releasing hormone (GnRH) which ultimately regulates fertility. The NPFF receptors modulate pain processing and may influence opioid peptide effects in the brain. These interactions suggest the importance of these receptors in the neuroendocrine and nociceptive systems.\u003cbr\u003e\nPathways\u003cbr\u003e\nNPFF1 and NPFF2 receptors and GPR54 play important roles in neuroendocrine pathways and reproductive hormonal regulation. The Kisspeptin-GPR54 signaling pathway is essential for the hypothalamic-pituitary-gonadal axis influencing reproductive development and function. GPR54 interacting with proteins such as GnRH coordinates the onset of puberty and fertility. This pathway is also integrally linked to energy homeostasis involving proteins like leptin which modulates its activity.\u003cbr\u003e\nDisruptions in the signaling of these receptors are associated with certain reproductive and neurological conditions. Abnormal GPR54 and Kisspeptin function have been linked to reproductive disorders including hypogonadotropic hypogonadism a condition marked by reduced sexual development. In the context of pain modulation alterations in NPFF receptor signaling have implications in chronic pain disorders. In both cases related proteins such as GnRH and opioids may exhibit dysregulated activity exacerbating these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847481446569,"sku":"ab120181","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab120181","provider":"Iright","version":"1.0","type":"link"}