{"product_id":"abcam-ab120183","title":"Abcam, ab120183, Angiotensin II (human), Vasoconstrictor peptide","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nAngiotensin II (Angiotensin II) (ab120183) is a vasoconstrictor and a bioactive peptide of the renin\/angiotensin system. MW 1046.2. - Available in different sizes to fit your experimental needs - Cited in over 20 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:4474-91-3,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:1046.2 Da,\u003cbr\u003e\nMolecular formula:C50H71N13O12,\u003cbr\u003e\nPubChem:172198,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 1mg\/ml,\u003cbr\u003e\nBiochemical name:Angiotensin II,\u003cbr\u003e\nCanonical smiles:CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N,\u003cbr\u003e\nIsomeric smiles:CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N,\u003cbr\u003e\nInChi:InChI=1S\/C50H71N13O12\/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66\/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)\/t28-,33-,34-,35-,36-,37-,38-,40-,41-\/m0\/s1,\u003cbr\u003e\nInChiKey:CZGUSIXMZVURDU-JZXHSEFVSA-N,\u003cbr\u003e\nIUPAC Name:(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nCheck out our range of Vasoconstrictor peptide biochemicals\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAGTR1 and AGTR2 have implications in hypertension and heart failure. Overactivation of AGTR1 is often linked with hypertension due to its vasoconstrictive action and fluid retention. Angiotensin receptor blockers (ARBs) target AGTR1 to treat hypertension by inhibiting angiotensin II binding. AGTR2 by mediating vasodilation plays a protective role in cardiovascular diseases but can also get involved in pathological conditions like fibrosis when dysregulated. Both receptors but predominantly AGTR1 associate with conditions like diabetic nephropathy because they affect renal function. The angiotensin-converting enzyme (ACE) remains a critical upstream regulator in these disease contexts as it modulates the production of angiotensin II.\u003cbr\u003e\nPathways\u003cbr\u003e\nAGTR1 and AGTR2 interact mainly with the renin-angiotensin-aldosterone system (RAAS) and counter-regulatory pathways like nitric oxide production. AGTR1 activation by angiotensin II influences the RAAS by triggering G-protein signaling cascades leading to the activation of phospholipase C and subsequent inositol triphosphate production. This pathway results in calcium release promoting muscle contraction. AGTR2 can modulate nitric oxide and bradykinin pathways providing vasodilation and antiproliferative effects. Proteins like angiotensin-converting enzyme (ACE) and renin help regulate these pathways through their role in converting angiotensinogen to angiotensin I then to angiotensin II.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese receptors function distinctly despite both interacting with the angiotensin II peptide. AGTR1 is the major mediator of the angiotensin II-induced vasoconstriction and aldosterone secretion facilitating sodium retention and influencing cardiovascular function. AGTR2 although it binds the same peptide is involved in cellular growth and differentiation displaying roles in neuroprotection and promoting vasodilation. These receptors do not form complexes like ion channels but function independently to fine-tune physiological responses.\u003cbr\u003e\nAngiotensin II Type 1 Receptor (AGTR1) and Angiotensin II Type 2 Receptor (AGTR2) play key roles in the renin-angiotensin system which regulates blood pressure and fluid balance. AGTR1 also called AT1 receptor typically binds angiotensin II a vasoconstrictor peptide leading to vasoconstriction and an increase in blood pressure. AGTR1 has a molecular mass of approximately 41 kDa and primarily expresses in vascular smooth muscle cells the heart liver kidney and adrenal gland. AGTR2 often called AT2 receptor shares similar angiotensin II binding but can mediate effects counter to AGTR1 such as vasodilation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847395332265,"sku":"ab120183","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab120183","provider":"Iright","version":"1.0","type":"link"}