{"product_id":"abcam-ab120374","title":"Abcam, ab120374, Ro 31-8220 mesylate (Bisindolylmaleimide IX), Protein kinase inhibitor","description":"\u003cp\u003eSize: 1mg \/ 5mg \/ 10mg\u003cbr\u003e\nMW 553.7 Da, Purity \u0026gt;98%. Widely used as a cell-permeable, reversible, competitive protein kinase C inhibitor. Also potently inhibits wide range of kinases inlcuding RSK1, RSK2, PRK2, PKCα, PKD1, MSK1, GSK3β, CDK2-cyclin A and PIM3, as well as PKCα. Also available in simple stock solutions (ab146723) - add 1 ml of water to get an exact, ready-to-use concentration.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:138489-18-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nMolecular weight:553.7 Da,\u003cbr\u003e\nMolecular formula:C26H27N5O5S2,\u003cbr\u003e\nPubChem:11628205,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO and organic solvents. Solubility in these solvents is approximately 20 mg\/mL.,\u003cbr\u003e\nBiochemical name:Bisindolylmaleimide IX mesylate,\u003cbr\u003e\nBiological description:Widely used as a cell-permeable, reversible, competitive protein kinase C inhibitor. Also potently inhibits wide range of kinases inlcuding RSK1, RSK2, PRK2, PKCα, PKD1, MSK1, GSK3β, CDK2-cyclin A and PIM3, as well as PKCα.Also available in simple stock solutions (ab146723) - add 1 ml of water to get an exact, ready-to-use concentration.,\u003cbr\u003e\nCanonical smiles:CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O,\u003cbr\u003e\nInChi:InChI=1S\/C25H23N5O2S.CH4O3S\/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4\/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4),\u003cbr\u003e\nInChiKey:SAWVGDJBSPLRRB-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:methanesulfonic acid;3-[3-[4-(1-methylindol-3-yl)-2,5-dioxopyrrol-3-yl]indol-1-yl]propyl carbamimidothioate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nERK2 also known as extracellular signal-regulated kinase 2 is a protein that plays a role in the MAP kinase signaling pathway which is important for various cellular processes. It has a mass of approximately 42 kDa. ERK2 expression occurs across many tissues with high levels in the brain heart and skeletal muscle. SIRT2 or sirtuin 2 is an NAD+-dependent deacetylase involved in metabolic regulation and has a mass of about 43 kDa. It is found in the cytoplasm and nuclear compartments in several cell types. HIPK1 or homeodomain-interacting protein kinase 1 functions as a serine\/threonine kinase and its mass is about 133 kDa. It is expressed in the nucleus in tissues including the brain and kidney.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nERK2 SIRT2 and HIPK1 participate in significant cellular regulation. ERK2 acts in signal transduction to regulate cell division and differentiation. SIRT2 deacetylates proteins contributing to the regulation of glucose homeostasis and stress responses. HIPK1 interacts with transcription factors modulating gene expression in response to cellular stress. These proteins might participate in larger complexes that influence cellular responses tissues development and homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nERK2 is an important component of the MAPK\/ERK pathway involved in transmitting signals from the cell surface to the DNA influencing growth and survival. SIRT2 participates in the regulation of the insulin signaling pathway affecting metabolic processes. Both proteins intersect through their modulation of cell cycle progression and apoptotic pathways. HIPK1 plays roles in the Wnt signaling pathway linking to transcriptional regulation and cell fate determination and it also interacts with proteins in these pathways to influence cell survival and differentiation.\u003cbr\u003e\nERK2 SIRT2 and HIPK1 serve as contributors to different pathological conditions. Hyperactivity of ERK2 correlates with cancer progression due to its impact on cell proliferation. SIRT2 involvement connects to neurodegenerative diseases like Parkinson’s through its regulation of cellular stress responses. HIPK1's dysregulation may link to cancer development as well. These proteins often engage with others like protein kinase A (PKA) in cancer or alpha-synuclein in neurodegenerative disorders influencing disease outcomes and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847443697833,"sku":"ab120374","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab120374","provider":"Iright","version":"1.0","type":"link"}