{"product_id":"abcam-ab120600","title":"Abcam, ab120600, Chelerythrine chloride, Cell-permeable protein kinase C inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 383.8 Da, Purity \u0026gt;98%. Cell-permeable, selective inhibitor of protein kinase C (IC 50  = 0.66 μM); Competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Activates MAPK pathways, independent of PKC inhibition. Inhibits Bcl XL  function (IC 50  = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:3895-92-9,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:383.8 Da,\u003cbr\u003e\nMolecular formula:C21H18ClNO4,\u003cbr\u003e\nPubChem:72311,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 10 mMSoluble in water to 10 mM,\u003cbr\u003e\nBiochemical name:Chelerythrine chloride,\u003cbr\u003e\nBiological description:Cell-permeable, selective inhibitor of protein kinase C (IC50 = 0.66 μM); Competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Activates MAPK pathways, independent of PKC inhibition. Inhibits BclXL function (IC50 = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines.,\u003cbr\u003e\nCanonical smiles:C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-],\u003cbr\u003e\nInChi:InChI=1S\/C21H18NO4.ClH\/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;\/h4-10H,11H2,1-3H3;1H\/q+1;\/p-1,\u003cbr\u003e\nInChiKey:WEEFNMFMNMASJY-UHFFFAOYSA-M,\u003cbr\u003e\nIUPAC Name:1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847428133033,"sku":"ab120600","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab120600","provider":"Iright","version":"1.0","type":"link"}