{"product_id":"abcam-ab120633","title":"Abcam, ab120633, DAPT, gamma-Secretase inhibitor","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nγ-Secretase inhibitor. Inhibits Notch signalling in vitro. Inhibits total Aβ and Aβ42 production in human primary cultures (IC50 values are 115 and 200 nM, respectively) with no effect on APPα and APPβ levels. MW 432.5. - Blood-brain barrier (BBB) permeable - 3D Growth matrix component and component of cerebral organoid differentiation media - Available in different sizes to fit your experimental needs\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:208255-80-5,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:432.5 Da,\u003cbr\u003e\nMolecular formula:C23H26F2N2O4,\u003cbr\u003e\nPubChem:5311272,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:Dapt,\u003cbr\u003e\nBiological description:γ-Secretase inhibitor. Inhibits Notch signalling in vitro. Inhibits total Aβ and Aβ42 production in human primary cultures (IC50 values are 115 and 200 nM, respectively) with no effect on APPα and APPβ levels. Blood-brain barrier permeable. 3D Growth matrix component and component of cerebral organoid differentiation media.,\u003cbr\u003e\nCanonical smiles:CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F,\u003cbr\u003e\nIsomeric smiles:C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F,\u003cbr\u003e\nInChi:InChI=1S\/C23H26F2N2O4\/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4\/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)\/t14-,20-\/m0\/s1,\u003cbr\u003e\nInChiKey:DWJXYEABWRJFSP-XOBRGWDASA-N,\u003cbr\u003e\nIUPAC Name:tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nCheck out our range of gamma-Secretase inhibitors\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847396544681,"sku":"ab120633","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab120633","provider":"Iright","version":"1.0","type":"link"}