{"product_id":"abcam-ab120952","title":"Abcam, ab120952, Stattic, STAT3 inhibitor","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 211.2 Da, Purity \u0026gt;99%. Selective STAT3 inhibitor. Inhibits activation, dimerization and nuclear translocation of STAT3 by interacting with the SH2 domain. Displays selectivity over STAT1, STAT5, c-Myc\/Max, Jun\/Jun and Lck. Induces apoptosis  in vitro  and  in vivo .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:19983-44-9,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:211.2 Da,\u003cbr\u003e\nMolecular formula:C8H5NO4S,\u003cbr\u003e\nPubChem:2779853,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:Stattic,\u003cbr\u003e\nBiological description:Selective STAT3 inhibitor. Inhibits activation, dimerization and nuclear translocation of STAT3 by interacting with the SH2 domain. Displays selectivity over STAT1, STAT5, c-Myc\/Max, Jun\/Jun and Lck. Induces apoptosis in vitro and in vivo.,\u003cbr\u003e\nCanonical smiles:C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-],\u003cbr\u003e\nInChi:InChI=1S\/C8H5NO4S\/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7\/h1-5H,\u003cbr\u003e\nInChiKey:ZRRGOUHITGRLBA-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:6-nitro-1-benzothiophene 1,1-dioxide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSignal Transducer and Activator of Transcription 3 (STAT3) also called p-stat3 or phospho-STAT3 is a critical transcription factor involved in various cellular processes. The molecular weight of STAT3 is approximately 92 kDa. This protein is expressed broadly across many tissues and cell types. Mechanically upon cytokine or growth factor stimulation STAT3 undergoes phosphorylation resulting in dimerization. This phosphorylated form often referred to as phospho-Stat3 or p-STAT3 translocates to the nucleus where it binds specific DNA sequences to modulate gene transcription.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSTAT3 is an important player in regulating cell growth and apoptosis. It functions not only as a transcription factor but also as part of a larger protein complex that operates within the cell nucleus to influence gene expression. This multifaceted role enables STAT3 to control the expression of genes related to cell proliferation survival and differentiation impacting various biological processes. These functions highlight its importance in tissue homeostasis and response to extracellular signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nSTAT3 is actively involved in the JAK-STAT signaling pathway a principal route for many cytokines and growth factors and the MAPK pathway. STAT3 interacts with proteins such as JAK kinases which phosphorylate Stat3 and initiate the STAT3 signaling cascade. Additionally it closely associates with the protein Raf1 in the MAPK pathway linking external signals to transcriptional responses. These pathways play a significant role in immune response inflammation and growth signaling.\u003cbr\u003e\nResearchers have implicated STAT3 in cancer and autoimmune diseases. Persistent activation of STAT3 is often observed in various cancers including breast and lung cancer promoting oncogenesis through altered gene expression. Additionally abnormal STAT3 signaling is associated with autoimmune conditions such as rheumatoid arthritis. The interplay between STAT3 and proteins like IL-6 in these diseases highlights its potential as a therapeutic target for intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847395397801,"sku":"ab120952","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab120952","provider":"Iright","version":"1.0","type":"link"}