{"product_id":"abcam-ab121099","title":"Abcam, ab121099, Anti-MORC4 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MORC4 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MORC4 aa 650-800.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MORC4 aa 650-800. The exact immunogen used to generate this antibody is proprietary information.Q8TE76\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMORC4 also known as MORC family CW-type zinc finger protein 4 is a protein that plays a role in chromatin remodeling and DNA isolation. MORC4 has an approximate molecular mass of 117 kDa. Expression occurs widely but is especially present in tissues such as testis and ovary indicating its involvement in reproductive processes. This distribution hints that MORC4 may have a specialized function in regulating gene expression within these cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMORC4 functions as part of the chromatin remodeling complex which influences gene transcription by modifying the chromatin structure. It acts by binding to particular DNA sequences and altering chromatin's accessibility. MORC4 interacts with other proteins in the complex such as histone acetyltransferases and deacetylases which further adjust chromatin structure and recruit additional factors important for gene regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nMORC4 is an active participant in the DNA repair and signal transduction pathways. It supports DNA repair mechanisms through its interaction with repair-related proteins like PARP1. Additionally MORC4 influences the MAPK signaling pathway working with proteins such as ERK1\/2 which are key in cell proliferation and stress responses.\u003cbr\u003e\nMORC4 has associations with certain cancers and infertility. Mutations or dysregulation in MORC4 expression relate to some cancer types including ovarian and testicular cancer due to its role in cell cycle progression and apoptosis. Furthermore abnormalities in MORC4 may contribute to infertility connecting with proteins like BRCA1 that influence DNA damage repair an essential process for maintaining healthy reproductive cells.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854166118569,"sku":"ab121099","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab121099","provider":"Iright","version":"1.0","type":"link"}