{"product_id":"abcam-ab121146","title":"Abcam, ab121146, Anti-TAGLN2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TAGLN2 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse, Rat samples. Cited in 12 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TAGLN2 aa 1-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TAGLN2 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.P37802\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTAGLN2 also known as Transgelin-2 is a protein with a mass of approximately 22 kDa. It functions as an actin-binding protein playing a role in the stabilization of actin filaments. This activity is important for the regulation of cellular shape and motility. TAGLN2 expression is present in various tissues with high levels seen in smooth muscle cells. Additionally its expression in non-muscle tissues indicates a versatile function in the cytoskeletal dynamics of different cell types.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein aids in maintaining cell structure and facilitates cell movement and adhesion. TAGLN2 is a monomer and does not form complexes but interacts closely with actin to regulate cytoskeletal processes. It acts as a modulator of actin filament organization which impacts cellular responses. The protein supports processes such as wound healing and embryonic development by influencing the migration and invasion of cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nTAGLN2 influences cellular mechanisms related to the actin cytoskeleton structure and dynamics. It plays a role in the Rho signaling pathway which is essential for cytoskeletal rearrangement and maintaining cellular tension. The protein associates with RhoA a small GTPase which is involved in mediating various functions including contractility and motility. Through RhoA TAGLN2 impacts cell morphology and stress fiber formation.\u003cbr\u003e\nAbnormal expression or function of TAGLN2 connects with different pathological conditions like cancer and cardiovascular diseases. Overexpression of TAGLN2 has been linked to enhanced tumor cell migration and metastasis making it relevant in cancer progression studies. The protein also associates with TRPC6 in cardiovascular disorders where dysregulation may lead to altered vascular function contributing to the disease state. Insights into TAGLN2 can aid in developing therapeutic strategies for managing these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848648478889,"sku":"ab121146","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab121146","provider":"Iright","version":"1.0","type":"link"}